Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by chronic motor and phonic tics, with a higher prevalence among boys. This condition can significantly impact patients’ learning and daily life. Due to the limited efficacy and potential side effects of pharmacological treatments f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1441019/full |
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| author | Shuang Zhao Shuang Zhao Qizu Jin Qi Yang Jing Liu Yun Lu Yun Lu Haibo Ai |
| author_facet | Shuang Zhao Shuang Zhao Qizu Jin Qi Yang Jing Liu Yun Lu Yun Lu Haibo Ai |
| author_sort | Shuang Zhao |
| collection | DOAJ |
| description | Tourette syndrome (TS) is a neuropsychiatric disorder characterized by chronic motor and phonic tics, with a higher prevalence among boys. This condition can significantly impact patients’ learning and daily life. Due to the limited efficacy and potential side effects of pharmacological treatments for TS, there is a critical need to develop novel, tailored therapeutic strategies. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have been proposed as potential treatments for TS, and have shown promising results. Here, we report a case of refractory TS, in which low-frequency rTMS was delivered to the left supplementary motor area (SMA), combined with tDCS targeting the primary motor cortex (M1) and the cerebellum, with the cathode positioned over the right M1 and the anode over the left cerebellum. This is the first reported case using a multi-target combination therapy for TS. This treatment yielded favorable outcomes and maintained good efficacy during a three-month follow-up period. Although larger-scale trials are needed, our findings pave the way for the application of non-invasive brain stimulation techniques in TS, offering a transformative path to improve treatment outcomes and quality of life for those with TS. |
| format | Article |
| id | doaj-art-d6bab3eef404438caa2b4ffc5a19794f |
| institution | OA Journals |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-d6bab3eef404438caa2b4ffc5a19794f2025-08-20T02:26:24ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-01-011810.3389/fnhum.2024.14410191441019Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case reportShuang Zhao0Shuang Zhao1Qizu Jin2Qi Yang3Jing Liu4Yun Lu5Yun Lu6Haibo Ai7Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaClinical Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, ChinaThe Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, ChinaThe Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaClinical Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, ChinaTourette syndrome (TS) is a neuropsychiatric disorder characterized by chronic motor and phonic tics, with a higher prevalence among boys. This condition can significantly impact patients’ learning and daily life. Due to the limited efficacy and potential side effects of pharmacological treatments for TS, there is a critical need to develop novel, tailored therapeutic strategies. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have been proposed as potential treatments for TS, and have shown promising results. Here, we report a case of refractory TS, in which low-frequency rTMS was delivered to the left supplementary motor area (SMA), combined with tDCS targeting the primary motor cortex (M1) and the cerebellum, with the cathode positioned over the right M1 and the anode over the left cerebellum. This is the first reported case using a multi-target combination therapy for TS. This treatment yielded favorable outcomes and maintained good efficacy during a three-month follow-up period. Although larger-scale trials are needed, our findings pave the way for the application of non-invasive brain stimulation techniques in TS, offering a transformative path to improve treatment outcomes and quality of life for those with TS.https://www.frontiersin.org/articles/10.3389/fnhum.2024.1441019/fullTourette syndromerepetitive transcranial magnetic stimulationrTMStranscranial direct current stimulationtDCS |
| spellingShingle | Shuang Zhao Shuang Zhao Qizu Jin Qi Yang Jing Liu Yun Lu Yun Lu Haibo Ai Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report Frontiers in Human Neuroscience Tourette syndrome repetitive transcranial magnetic stimulation rTMS transcranial direct current stimulation tDCS |
| title | Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report |
| title_full | Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report |
| title_fullStr | Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report |
| title_full_unstemmed | Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report |
| title_short | Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report |
| title_sort | multi target combination treatment with rtms and tdcs for tourette syndrome a case report |
| topic | Tourette syndrome repetitive transcranial magnetic stimulation rTMS transcranial direct current stimulation tDCS |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1441019/full |
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