Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies?
Background. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. Methods. A prospective multicenter study was designed to assess CCE diagnostic yield...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/1507914 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683844182048768 |
|---|---|
| author | Cristina Alvarez-Urturi Gloria Fernández-Esparrach Inés Ana Ibáñez Cristina Rodríguez De Miguel Josep Maria Dedeu Xavier Bessa Henry Córdova Maria Pellisé Francesc Balaguer Angels Ginés Luis Barranco Isis K. Araujo Montserrat Andreu Josep Llach Antoni Castells Begoña González-Suarez |
| author_facet | Cristina Alvarez-Urturi Gloria Fernández-Esparrach Inés Ana Ibáñez Cristina Rodríguez De Miguel Josep Maria Dedeu Xavier Bessa Henry Córdova Maria Pellisé Francesc Balaguer Angels Ginés Luis Barranco Isis K. Araujo Montserrat Andreu Josep Llach Antoni Castells Begoña González-Suarez |
| author_sort | Cristina Alvarez-Urturi |
| collection | DOAJ |
| description | Background. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. Methods. A prospective multicenter study was designed to assess CCE diagnostic yield in a cohort of asymptomatic individuals with a family history of CRC. CCE and colonoscopy were performed on the same day by 2 endoscopists who were blinded to the results of the other procedure. Results. Fifty-three participants were enrolled. The sensitivity, specificity, PPV, and NPV of CCE for detecting advanced adenomas were 100%, 98%, 67%, and 100%. Sensitivity, specificity, PPV, and NPV of CCE for the diagnosis of individuals with polyps were 87%, 97%, 93%, and 88%, respectively. CCE identify 100% of individuals with significant or advanced lesions. Overall cleanliness was adequate by 60.7% of them. The PEG-ascorbic boost seems to improve colon cleanliness, with similar colonic transit time. Conclusion. CCE is a promising tool, but it has to be considered as an alternative technique in this population in order to reduce the number of colonoscopies performed. More studies are needed to understand appropriate screening follow-up intervals and optimize the bowel preparation regimen. |
| format | Article |
| id | doaj-art-d6b5c329b7d64fda810089a8c8b607d6 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d6b5c329b7d64fda810089a8c8b607d62025-08-20T03:23:39ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/15079141507914Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies?Cristina Alvarez-Urturi0Gloria Fernández-Esparrach1Inés Ana Ibáñez2Cristina Rodríguez De Miguel3Josep Maria Dedeu4Xavier Bessa5Henry Córdova6Maria Pellisé7Francesc Balaguer8Angels Ginés9Luis Barranco10Isis K. Araujo11Montserrat Andreu12Josep Llach13Antoni Castells14Begoña González-Suarez15Department of Gastroenterology, Hospital del Mar, UAB, Parc de Salut Mar, Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainDepartment of Gastroenterology, Hospital del Mar, UAB, Parc de Salut Mar, Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainDepartment of Gastroenterology, Hospital del Mar, UAB, Parc de Salut Mar, Barcelona, Catalonia, SpainDepartment of Gastroenterology, Hospital del Mar, UAB, Parc de Salut Mar, Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainDepartment of Gastroenterology, Hospital del Mar, UAB, Parc de Salut Mar, Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainDepartment of Gastroenterology, Hospital del Mar, UAB, Parc de Salut Mar, Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainGastroenterology Department, Endoscopy Unit, ICMDiM, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Catalonia, SpainBackground. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. Methods. A prospective multicenter study was designed to assess CCE diagnostic yield in a cohort of asymptomatic individuals with a family history of CRC. CCE and colonoscopy were performed on the same day by 2 endoscopists who were blinded to the results of the other procedure. Results. Fifty-three participants were enrolled. The sensitivity, specificity, PPV, and NPV of CCE for detecting advanced adenomas were 100%, 98%, 67%, and 100%. Sensitivity, specificity, PPV, and NPV of CCE for the diagnosis of individuals with polyps were 87%, 97%, 93%, and 88%, respectively. CCE identify 100% of individuals with significant or advanced lesions. Overall cleanliness was adequate by 60.7% of them. The PEG-ascorbic boost seems to improve colon cleanliness, with similar colonic transit time. Conclusion. CCE is a promising tool, but it has to be considered as an alternative technique in this population in order to reduce the number of colonoscopies performed. More studies are needed to understand appropriate screening follow-up intervals and optimize the bowel preparation regimen.http://dx.doi.org/10.1155/2017/1507914 |
| spellingShingle | Cristina Alvarez-Urturi Gloria Fernández-Esparrach Inés Ana Ibáñez Cristina Rodríguez De Miguel Josep Maria Dedeu Xavier Bessa Henry Córdova Maria Pellisé Francesc Balaguer Angels Ginés Luis Barranco Isis K. Araujo Montserrat Andreu Josep Llach Antoni Castells Begoña González-Suarez Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies? Gastroenterology Research and Practice |
| title | Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies? |
| title_full | Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies? |
| title_fullStr | Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies? |
| title_full_unstemmed | Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies? |
| title_short | Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies? |
| title_sort | accuracy of colon capsule endoscopy in detecting colorectal polyps in individuals with familial colorectal cancer could we avoid colonoscopies |
| url | http://dx.doi.org/10.1155/2017/1507914 |
| work_keys_str_mv | AT cristinaalvarezurturi accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT gloriafernandezesparrach accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT inesanaibanez accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT cristinarodriguezdemiguel accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT josepmariadedeu accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT xavierbessa accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT henrycordova accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT mariapellise accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT francescbalaguer accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT angelsgines accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT luisbarranco accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT isiskaraujo accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT montserratandreu accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT josepllach accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT antonicastells accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies AT begonagonzalezsuarez accuracyofcoloncapsuleendoscopyindetectingcolorectalpolypsinindividualswithfamilialcolorectalcancercouldweavoidcolonoscopies |