Microfluidic device for both active and passive cell separation techniques: A review
Microfluidic separation of particles and cells has been extensively developed in recent years in a wide range of applications of sciences, engineering, and industry. At the same time, this area has been explored within the framework of interdisciplinary study, resulting in several experiments conduc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053924000936 |
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| author | Muhammad Asraf Mansor Muhammad Asyraf Jamrus Chong Kar Lok Mohd Ridzuan Ahmad Michal Petrů Seyed Saeid Rahimian Koloor |
| author_facet | Muhammad Asraf Mansor Muhammad Asyraf Jamrus Chong Kar Lok Mohd Ridzuan Ahmad Michal Petrů Seyed Saeid Rahimian Koloor |
| author_sort | Muhammad Asraf Mansor |
| collection | DOAJ |
| description | Microfluidic separation of particles and cells has been extensively developed in recent years in a wide range of applications of sciences, engineering, and industry. At the same time, this area has been explored within the framework of interdisciplinary study, resulting in several experiments conducted in this field. Due to the heterogeneity of cells, label-free methods that utilize the inherent physical properties of cells to separate, offer more advantages including high throughput, simple design, reduced sample volumes, and low device cost. This paper comprehensively studies the latest progress in microfluidic technology for both active and passive cell separation techniques. In order to limit the extent of this work, our primary emphasis is on six common methods of cell separation: acoustophoresis, dielectrophoresis, magnetophoresis, inertial, pinched flow fractionation (PFF), and deterministic lateral displacement (DLD). We elaborate on the efficiency, throughput rate, and clogging in microfluidic devices. In addition, the advantages and limitations of both microfluidics devices were discussed. |
| format | Article |
| id | doaj-art-d6ae34375248449fb3c93dd687c9ebbe |
| institution | OA Journals |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-d6ae34375248449fb3c93dd687c9ebbe2025-08-20T02:35:24ZengElsevierSensors and Actuators Reports2666-05392025-06-01910027710.1016/j.snr.2024.100277Microfluidic device for both active and passive cell separation techniques: A reviewMuhammad Asraf Mansor0Muhammad Asyraf Jamrus1Chong Kar Lok2Mohd Ridzuan Ahmad3Michal Petrů4Seyed Saeid Rahimian Koloor5Department of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaDepartment of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaDepartment of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaDepartment of Control and Mechatronics Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia; Corresponding authors.Department of Mechanical Engineering, Technical University of Liberec, Liberec, Czech RepublicInstitute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Liberec, Czech Republic; Corresponding authors.Microfluidic separation of particles and cells has been extensively developed in recent years in a wide range of applications of sciences, engineering, and industry. At the same time, this area has been explored within the framework of interdisciplinary study, resulting in several experiments conducted in this field. Due to the heterogeneity of cells, label-free methods that utilize the inherent physical properties of cells to separate, offer more advantages including high throughput, simple design, reduced sample volumes, and low device cost. This paper comprehensively studies the latest progress in microfluidic technology for both active and passive cell separation techniques. In order to limit the extent of this work, our primary emphasis is on six common methods of cell separation: acoustophoresis, dielectrophoresis, magnetophoresis, inertial, pinched flow fractionation (PFF), and deterministic lateral displacement (DLD). We elaborate on the efficiency, throughput rate, and clogging in microfluidic devices. In addition, the advantages and limitations of both microfluidics devices were discussed.http://www.sciencedirect.com/science/article/pii/S2666053924000936Cell separationMicrofluidicActive cell separationPassive cell separation |
| spellingShingle | Muhammad Asraf Mansor Muhammad Asyraf Jamrus Chong Kar Lok Mohd Ridzuan Ahmad Michal Petrů Seyed Saeid Rahimian Koloor Microfluidic device for both active and passive cell separation techniques: A review Sensors and Actuators Reports Cell separation Microfluidic Active cell separation Passive cell separation |
| title | Microfluidic device for both active and passive cell separation techniques: A review |
| title_full | Microfluidic device for both active and passive cell separation techniques: A review |
| title_fullStr | Microfluidic device for both active and passive cell separation techniques: A review |
| title_full_unstemmed | Microfluidic device for both active and passive cell separation techniques: A review |
| title_short | Microfluidic device for both active and passive cell separation techniques: A review |
| title_sort | microfluidic device for both active and passive cell separation techniques a review |
| topic | Cell separation Microfluidic Active cell separation Passive cell separation |
| url | http://www.sciencedirect.com/science/article/pii/S2666053924000936 |
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