Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era
Pneumococcal conjugate vaccines (PCVs) have resulted in a dramatic reduction in vaccine-type disease in both children and adults. Several expanded PCVs have recently been approved and incorporated into immunization programs for children and adults, with numerous additional vaccine formulations in de...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2491855 |
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| author | David C. LaFon |
| author_facet | David C. LaFon |
| author_sort | David C. LaFon |
| collection | DOAJ |
| description | Pneumococcal conjugate vaccines (PCVs) have resulted in a dramatic reduction in vaccine-type disease in both children and adults. Several expanded PCVs have recently been approved and incorporated into immunization programs for children and adults, with numerous additional vaccine formulations in development or undergoing evaluation in clinical trials. This concise review provides an introduction to the evolving approaches to vaccine evaluation used in the decades since the initial studies of PCV7, followed by a contemporary assessment of challenges and future directions for studies of efficacy, immunogenicity, and real-world effectiveness. |
| format | Article |
| id | doaj-art-d6adb37a2e064c0fb2ebf85f76eaca2f |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-d6adb37a2e064c0fb2ebf85f76eaca2f2025-08-20T03:03:21ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2491855Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine eraDavid C. LaFon0Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USAPneumococcal conjugate vaccines (PCVs) have resulted in a dramatic reduction in vaccine-type disease in both children and adults. Several expanded PCVs have recently been approved and incorporated into immunization programs for children and adults, with numerous additional vaccine formulations in development or undergoing evaluation in clinical trials. This concise review provides an introduction to the evolving approaches to vaccine evaluation used in the decades since the initial studies of PCV7, followed by a contemporary assessment of challenges and future directions for studies of efficacy, immunogenicity, and real-world effectiveness.https://www.tandfonline.com/doi/10.1080/21645515.2025.2491855Streptococcus pneumoniaeimmunoassaysepidemiologyclinical trialsvaccine response |
| spellingShingle | David C. LaFon Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era Human Vaccines & Immunotherapeutics Streptococcus pneumoniae immunoassays epidemiology clinical trials vaccine response |
| title | Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era |
| title_full | Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era |
| title_fullStr | Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era |
| title_full_unstemmed | Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era |
| title_short | Evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era |
| title_sort | evaluation of efficacy and effectiveness across the pneumococcal conjugate vaccine era |
| topic | Streptococcus pneumoniae immunoassays epidemiology clinical trials vaccine response |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2491855 |
| work_keys_str_mv | AT davidclafon evaluationofefficacyandeffectivenessacrossthepneumococcalconjugatevaccineera |