The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates
Abstract Background and objective Newborns are particularly vulnerable to infection-related complications, including surgical site infections (SSIs). Chlorhexidine gluconate (CHG) demonstrates efficacy in reducing infant sepsis in resource-constrained settings. This study evaluated the effectiveness...
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| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | Egyptian Pediatric Association Gazette |
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| Online Access: | https://doi.org/10.1186/s43054-025-00399-y |
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| author | Tayseer Mostafa Gad Khaled Mohamed El-Asmar Nehal Mohamed El-Raggal Filsan Abdi Mahmoud Ayah Mohamed Shabana |
| author_facet | Tayseer Mostafa Gad Khaled Mohamed El-Asmar Nehal Mohamed El-Raggal Filsan Abdi Mahmoud Ayah Mohamed Shabana |
| author_sort | Tayseer Mostafa Gad |
| collection | DOAJ |
| description | Abstract Background and objective Newborns are particularly vulnerable to infection-related complications, including surgical site infections (SSIs). Chlorhexidine gluconate (CHG) demonstrates efficacy in reducing infant sepsis in resource-constrained settings. This study evaluated the effectiveness of preoperative bathing with 2% CHG compared to non-irritant plain soap in reducing postoperative wound infections following clean/clean-contaminated surgeries. Patients and methods This randomized trial involved 50 full-term newborns undergoing clean/clean-contaminated surgeries. Subjects were divided into two groups: CHG (2% chlorhexidine gluconate baths) and control (soap baths) groups, both administrated preoperatively. The primary outcome was the incidence of SSIs, while secondary outcomes included overall clinical parameters and the safety profile. Results The Chlorhexidine group showed lower rates of SSIs, mortality, and hospital stays (P < 0.01, 0.034, 0.041 respectively). Furthermore, patients in the CHG group required less postoperative mechanical ventilation and central line insertion (P < 0.05 for both). The application of CHG was also associated with a higher incidence of negative blood and wound cultures, with only transient, localized erythema occurring in only four treated neonates. Conclusion Preoperative bathing with 2% CHG significantly reduced postoperative SSIs in full-term neonates recovering from clean or clean-contaminated operations while demonstrating an excellent safety profile in this population. |
| format | Article |
| id | doaj-art-d6acb6a1d2db458c97bd12cf30a764c6 |
| institution | Kabale University |
| issn | 2090-9942 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Pediatric Association Gazette |
| spelling | doaj-art-d6acb6a1d2db458c97bd12cf30a764c62025-08-20T03:37:23ZengSpringerOpenEgyptian Pediatric Association Gazette2090-99422025-07-017311510.1186/s43054-025-00399-yThe effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonatesTayseer Mostafa Gad0Khaled Mohamed El-Asmar1Nehal Mohamed El-Raggal2Filsan Abdi Mahmoud3Ayah Mohamed Shabana4Ain Shams University HospitalsAin Shams University HospitalsAin Shams University HospitalsBenadir UniversitySuez UniversityAbstract Background and objective Newborns are particularly vulnerable to infection-related complications, including surgical site infections (SSIs). Chlorhexidine gluconate (CHG) demonstrates efficacy in reducing infant sepsis in resource-constrained settings. This study evaluated the effectiveness of preoperative bathing with 2% CHG compared to non-irritant plain soap in reducing postoperative wound infections following clean/clean-contaminated surgeries. Patients and methods This randomized trial involved 50 full-term newborns undergoing clean/clean-contaminated surgeries. Subjects were divided into two groups: CHG (2% chlorhexidine gluconate baths) and control (soap baths) groups, both administrated preoperatively. The primary outcome was the incidence of SSIs, while secondary outcomes included overall clinical parameters and the safety profile. Results The Chlorhexidine group showed lower rates of SSIs, mortality, and hospital stays (P < 0.01, 0.034, 0.041 respectively). Furthermore, patients in the CHG group required less postoperative mechanical ventilation and central line insertion (P < 0.05 for both). The application of CHG was also associated with a higher incidence of negative blood and wound cultures, with only transient, localized erythema occurring in only four treated neonates. Conclusion Preoperative bathing with 2% CHG significantly reduced postoperative SSIs in full-term neonates recovering from clean or clean-contaminated operations while demonstrating an excellent safety profile in this population.https://doi.org/10.1186/s43054-025-00399-yChlorhexidine gluconateSurgical site infectionsInfection controlWound sepsis |
| spellingShingle | Tayseer Mostafa Gad Khaled Mohamed El-Asmar Nehal Mohamed El-Raggal Filsan Abdi Mahmoud Ayah Mohamed Shabana The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates Egyptian Pediatric Association Gazette Chlorhexidine gluconate Surgical site infections Infection control Wound sepsis |
| title | The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates |
| title_full | The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates |
| title_fullStr | The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates |
| title_full_unstemmed | The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates |
| title_short | The effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates |
| title_sort | effectiveness of preoperative chlorhexidine gluconate in prevention of surgical site infections in neonates |
| topic | Chlorhexidine gluconate Surgical site infections Infection control Wound sepsis |
| url | https://doi.org/10.1186/s43054-025-00399-y |
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