Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients
Transient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing. Notably, Traditional Chinese Medicine (TCM) has demonstrated pharmacological effects through regulation of TRPA1. In this review, we su...
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| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1604765/full |
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| author | Yunlong Fang Yunlong Fang Chunxin Lei Chunxin Lei Zihan Wang Zihan Wang Longxiao Liu Longxiao Liu Yanyu Chen Yanyu Chen Feng Chen Feng Chen Jingxuan Li Jingxuan Li Zhikun Tu Zhikun Tu Qingwen Tao Yuan Xu |
| author_facet | Yunlong Fang Yunlong Fang Chunxin Lei Chunxin Lei Zihan Wang Zihan Wang Longxiao Liu Longxiao Liu Yanyu Chen Yanyu Chen Feng Chen Feng Chen Jingxuan Li Jingxuan Li Zhikun Tu Zhikun Tu Qingwen Tao Yuan Xu |
| author_sort | Yunlong Fang |
| collection | DOAJ |
| description | Transient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing. Notably, Traditional Chinese Medicine (TCM) has demonstrated pharmacological effects through regulation of TRPA1. In this review, we summarize the regulatory effects of TCM drugs and their active ingredients on TRPA1. A total of 31 TCM drugs were identified and categorized into three groups based on their function. Despite the progress in understanding the regulatory effects of TCM drugs and their constituents on TRPA1, further studies are needed to elucidate the molecular mechanisms involved. This review provides a molecular basis for the pharmacological effects of TCM drugs on TRPA1 regulation and offers evidence to support future research in this area. |
| format | Article |
| id | doaj-art-d6a8bdfe140a4f6283f473b53b921d45 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-d6a8bdfe140a4f6283f473b53b921d452025-08-20T03:24:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.16047651604765Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredientsYunlong Fang0Yunlong Fang1Chunxin Lei2Chunxin Lei3Zihan Wang4Zihan Wang5Longxiao Liu6Longxiao Liu7Yanyu Chen8Yanyu Chen9Feng Chen10Feng Chen11Jingxuan Li12Jingxuan Li13Zhikun Tu14Zhikun Tu15Qingwen Tao16Yuan Xu17National Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Shanxi University of Chinese Medicine, Taiyuan, Shanxi, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaGraduate School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaTransient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing. Notably, Traditional Chinese Medicine (TCM) has demonstrated pharmacological effects through regulation of TRPA1. In this review, we summarize the regulatory effects of TCM drugs and their active ingredients on TRPA1. A total of 31 TCM drugs were identified and categorized into three groups based on their function. Despite the progress in understanding the regulatory effects of TCM drugs and their constituents on TRPA1, further studies are needed to elucidate the molecular mechanisms involved. This review provides a molecular basis for the pharmacological effects of TCM drugs on TRPA1 regulation and offers evidence to support future research in this area.https://www.frontiersin.org/articles/10.3389/fphar.2025.1604765/fullTRPA1traditional Chinese medicineChinese herbal medicinal propertiesnatural compoundspainhyperalgesia |
| spellingShingle | Yunlong Fang Yunlong Fang Chunxin Lei Chunxin Lei Zihan Wang Zihan Wang Longxiao Liu Longxiao Liu Yanyu Chen Yanyu Chen Feng Chen Feng Chen Jingxuan Li Jingxuan Li Zhikun Tu Zhikun Tu Qingwen Tao Yuan Xu Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients Frontiers in Pharmacology TRPA1 traditional Chinese medicine Chinese herbal medicinal properties natural compounds pain hyperalgesia |
| title | Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients |
| title_full | Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients |
| title_fullStr | Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients |
| title_full_unstemmed | Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients |
| title_short | Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients |
| title_sort | regulation of transient receptor potential ankyrin 1 by traditional chinese medicine drugs and their active ingredients |
| topic | TRPA1 traditional Chinese medicine Chinese herbal medicinal properties natural compounds pain hyperalgesia |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1604765/full |
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