Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study
Background: Pregnancy outcomes in assisted reproductive technology (ART) are influenced by the ability of the embryos to create a pregnancy and maternal factors such as hormone levels to maintain and develop the pregnancy. This study investigated the role of β-human chorionic gonadotropin (β-hCG), a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
|
| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/abr.abr_285_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850225460547420160 |
|---|---|
| author | Fatemeh Davari Tanha Azam Rasti Hamideh Pakniat Shohreh Salimi Setudeh Amir Hosseini Mohammad Amin Rahimian Ghohroodi |
| author_facet | Fatemeh Davari Tanha Azam Rasti Hamideh Pakniat Shohreh Salimi Setudeh Amir Hosseini Mohammad Amin Rahimian Ghohroodi |
| author_sort | Fatemeh Davari Tanha |
| collection | DOAJ |
| description | Background:
Pregnancy outcomes in assisted reproductive technology (ART) are influenced by the ability of the embryos to create a pregnancy and maternal factors such as hormone levels to maintain and develop the pregnancy. This study investigated the role of β-human chorionic gonadotropin (β-hCG), anti-mullerian hormone (AMH), thyroid-stimulating hormone (TSH), and prolactin (PRL) in predicting pregnancy outcomes and determined cutoff values in women undergoing ARTs.
Materials and Methods:
This prospective study included 153 women who underwent infertility treatment in the Department of Reproductive Medicine of the Yas Hospital, Tehran University of Medical Sciences (Tehran, Iran). Serum β-hCG level on day 14 after embryo transfer and serum AMH, TSH, and PRL were measured. Patients with β-hCG levels >25 mIU/ml were included in the study. Finally, any statistically significant relationships between these serum values and clinical pregnancy and live birth rate were investigated. To predict pregnancy outcomes with β-hCG levels, a receiver operating characteristic curve was used to estimate the β-hCG cutoff values.
Results:
Serum β-hCG levels were significantly higher in live-birth patients than in other patients. The β-hCG cutoff value for live births was 830 mIU/ml, with an AUC of 0.5920, sensitivity of 61.04%, and specificity of 56.58%. Serum AMH, TSH, and PRL levels did not show any significant results.
Conclusions:
Serum β-hCG levels on day 14 after embryo transfer can be used to predict the probability of live birth in patients undergoing infertility treatment. |
| format | Article |
| id | doaj-art-d69fc6077aeb47ff90feb42e7b73dd42 |
| institution | OA Journals |
| issn | 2277-9175 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj-art-d69fc6077aeb47ff90feb42e7b73dd422025-08-20T02:05:21ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752025-05-01141454510.4103/abr.abr_285_23Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort StudyFatemeh Davari TanhaAzam RastiHamideh PakniatShohreh Salimi SetudehAmir HosseiniMohammad Amin Rahimian GhohroodiBackground: Pregnancy outcomes in assisted reproductive technology (ART) are influenced by the ability of the embryos to create a pregnancy and maternal factors such as hormone levels to maintain and develop the pregnancy. This study investigated the role of β-human chorionic gonadotropin (β-hCG), anti-mullerian hormone (AMH), thyroid-stimulating hormone (TSH), and prolactin (PRL) in predicting pregnancy outcomes and determined cutoff values in women undergoing ARTs. Materials and Methods: This prospective study included 153 women who underwent infertility treatment in the Department of Reproductive Medicine of the Yas Hospital, Tehran University of Medical Sciences (Tehran, Iran). Serum β-hCG level on day 14 after embryo transfer and serum AMH, TSH, and PRL were measured. Patients with β-hCG levels >25 mIU/ml were included in the study. Finally, any statistically significant relationships between these serum values and clinical pregnancy and live birth rate were investigated. To predict pregnancy outcomes with β-hCG levels, a receiver operating characteristic curve was used to estimate the β-hCG cutoff values. Results: Serum β-hCG levels were significantly higher in live-birth patients than in other patients. The β-hCG cutoff value for live births was 830 mIU/ml, with an AUC of 0.5920, sensitivity of 61.04%, and specificity of 56.58%. Serum AMH, TSH, and PRL levels did not show any significant results. Conclusions: Serum β-hCG levels on day 14 after embryo transfer can be used to predict the probability of live birth in patients undergoing infertility treatment.https://journals.lww.com/10.4103/abr.abr_285_23embryo transferhuman chorionic-gonadotropinpregnancy outcomes |
| spellingShingle | Fatemeh Davari Tanha Azam Rasti Hamideh Pakniat Shohreh Salimi Setudeh Amir Hosseini Mohammad Amin Rahimian Ghohroodi Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study Advanced Biomedical Research embryo transfer human chorionic-gonadotropin pregnancy outcomes |
| title | Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study |
| title_full | Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study |
| title_fullStr | Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study |
| title_full_unstemmed | Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study |
| title_short | Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study |
| title_sort | serum β hcg amh tsh and prl levels in predicting the outcome of early pregnancy 14 days after embryo transfer a prospective cohort study |
| topic | embryo transfer human chorionic-gonadotropin pregnancy outcomes |
| url | https://journals.lww.com/10.4103/abr.abr_285_23 |
| work_keys_str_mv | AT fatemehdavaritanha serumbhcgamhtshandprllevelsinpredictingtheoutcomeofearlypregnancy14daysafterembryotransferaprospectivecohortstudy AT azamrasti serumbhcgamhtshandprllevelsinpredictingtheoutcomeofearlypregnancy14daysafterembryotransferaprospectivecohortstudy AT hamidehpakniat serumbhcgamhtshandprllevelsinpredictingtheoutcomeofearlypregnancy14daysafterembryotransferaprospectivecohortstudy AT shohrehsalimisetudeh serumbhcgamhtshandprllevelsinpredictingtheoutcomeofearlypregnancy14daysafterembryotransferaprospectivecohortstudy AT amirhosseini serumbhcgamhtshandprllevelsinpredictingtheoutcomeofearlypregnancy14daysafterembryotransferaprospectivecohortstudy AT mohammadaminrahimianghohroodi serumbhcgamhtshandprllevelsinpredictingtheoutcomeofearlypregnancy14daysafterembryotransferaprospectivecohortstudy |