Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for unders...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7906724 |
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| _version_ | 1850174980215537664 |
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| author | Sudhanshu Shekhar Rabia Khan Ata Ul Razzaq Khan Fernanda Cristina Petersen |
| author_facet | Sudhanshu Shekhar Rabia Khan Ata Ul Razzaq Khan Fernanda Cristina Petersen |
| author_sort | Sudhanshu Shekhar |
| collection | DOAJ |
| description | Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for understanding the S. mitis-induced IgG isotype responses and have consequences for the development of an effective pneumococcal vaccine. |
| format | Article |
| id | doaj-art-d69af0630bd54eb9a36afa4a36a0c82e |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d69af0630bd54eb9a36afa4a36a0c82e2025-08-20T02:19:33ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/79067247906724Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 AntibodiesSudhanshu Shekhar0Rabia Khan1Ata Ul Razzaq Khan2Fernanda Cristina Petersen3Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, NorwayInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, NorwayInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, NorwayInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, NorwayHere we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for understanding the S. mitis-induced IgG isotype responses and have consequences for the development of an effective pneumococcal vaccine.http://dx.doi.org/10.1155/2019/7906724 |
| spellingShingle | Sudhanshu Shekhar Rabia Khan Ata Ul Razzaq Khan Fernanda Cristina Petersen Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies Journal of Immunology Research |
| title | Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies |
| title_full | Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies |
| title_fullStr | Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies |
| title_full_unstemmed | Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies |
| title_short | Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies |
| title_sort | mouse igg2a antibodies specific for the commensal streptococcus mitis show stronger cross reactivity with streptococcus pneumoniae than igg1 antibodies |
| url | http://dx.doi.org/10.1155/2019/7906724 |
| work_keys_str_mv | AT sudhanshushekhar mouseigg2aantibodiesspecificforthecommensalstreptococcusmitisshowstrongercrossreactivitywithstreptococcuspneumoniaethanigg1antibodies AT rabiakhan mouseigg2aantibodiesspecificforthecommensalstreptococcusmitisshowstrongercrossreactivitywithstreptococcuspneumoniaethanigg1antibodies AT ataulrazzaqkhan mouseigg2aantibodiesspecificforthecommensalstreptococcusmitisshowstrongercrossreactivitywithstreptococcuspneumoniaethanigg1antibodies AT fernandacristinapetersen mouseigg2aantibodiesspecificforthecommensalstreptococcusmitisshowstrongercrossreactivitywithstreptococcuspneumoniaethanigg1antibodies |