Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report
Iron Deficiency Anaemia (IDA) is a prevalent nutritional deficiency and a common haematological disorder characterised by low iron levels, which lead to reduced haemoglobin production, fatigue, pallor and diminished oxygen delivery. IDA increases the risk of venous thromboembolism by causing thrombo...
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JCDR Research and Publications Private Limited
2025-02-01
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| author | Satbir Kaur Malik Vineetha Naga Lakshmi Giduturi Sindhuri Goud Nimmala Vijayashree Gokhale |
| author_facet | Satbir Kaur Malik Vineetha Naga Lakshmi Giduturi Sindhuri Goud Nimmala Vijayashree Gokhale |
| author_sort | Satbir Kaur Malik |
| collection | DOAJ |
| description | Iron Deficiency Anaemia (IDA) is a prevalent nutritional deficiency and a common haematological disorder characterised by low iron levels, which lead to reduced haemoglobin production, fatigue, pallor and diminished oxygen delivery. IDA increases the risk of venous thromboembolism by causing thrombocytosis, venous stasis and hypercoagulability. Although iron deficiency is a rare risk factor, recognising it as a significant risk factor can help prevent pulmonary thromboembolism if detected early and treated. The most common inherited thrombophilias—such as Factor V Leiden mutation, prothrombin G20210A mutation and deficiencies in protein C, protein S and antithrombin III—are a group of genetic conditions that predispose individuals to thrombotic events by influencing various factors involved in the coagulation cascade. Deep Vein Thrombosis (DVT) is a common condition that is part of venous thromboembolism disorders and represents the third most common cause of death from cardiovascular disease, following heart attacks and strokes. Authors hereby, report a rare and complicated case involving a 44-year-old male patient who experienced Pulmonary Embolism (PE), DVT, IDA and underlying abnormalities in two key anticoagulant proteins: Protein C and Protein S. Anticoagulation with low molecular weight heparin was initiated to treat the PE and DVT. Based on the patient’s thrombophilia profile, a newer oral anticoagulant, rivaroxaban, was prescribed as a long-term anticoagulant. |
| format | Article |
| id | doaj-art-d697dfd9b50b43aa9679a017a1f39c90 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-d697dfd9b50b43aa9679a017a1f39c902025-02-01T11:39:15ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-02-011902010310.7860/JCDR/2025/74900.20563Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case ReportSatbir Kaur Malik0Vineetha Naga Lakshmi Giduturi1Sindhuri Goud Nimmala2Vijayashree Gokhale3Assistant Professor, Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.Junior Resident, Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.Junior Resident, Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.Professor, Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.Iron Deficiency Anaemia (IDA) is a prevalent nutritional deficiency and a common haematological disorder characterised by low iron levels, which lead to reduced haemoglobin production, fatigue, pallor and diminished oxygen delivery. IDA increases the risk of venous thromboembolism by causing thrombocytosis, venous stasis and hypercoagulability. Although iron deficiency is a rare risk factor, recognising it as a significant risk factor can help prevent pulmonary thromboembolism if detected early and treated. The most common inherited thrombophilias—such as Factor V Leiden mutation, prothrombin G20210A mutation and deficiencies in protein C, protein S and antithrombin III—are a group of genetic conditions that predispose individuals to thrombotic events by influencing various factors involved in the coagulation cascade. Deep Vein Thrombosis (DVT) is a common condition that is part of venous thromboembolism disorders and represents the third most common cause of death from cardiovascular disease, following heart attacks and strokes. Authors hereby, report a rare and complicated case involving a 44-year-old male patient who experienced Pulmonary Embolism (PE), DVT, IDA and underlying abnormalities in two key anticoagulant proteins: Protein C and Protein S. Anticoagulation with low molecular weight heparin was initiated to treat the PE and DVT. Based on the patient’s thrombophilia profile, a newer oral anticoagulant, rivaroxaban, was prescribed as a long-term anticoagulant.https://jcdr.net/articles/PDF/20563/74900_CE[Ra1]_F(SHU)_QC(PS_SS)_PF1(RI_SHU)_redo_PFA(SHU)_PB(RI_IS)_PN(IS).pdfiron deficiency anaemiaprotein c deficiencyprotein s deficiencyrivaroxabanthrombophilia profile |
| spellingShingle | Satbir Kaur Malik Vineetha Naga Lakshmi Giduturi Sindhuri Goud Nimmala Vijayashree Gokhale Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report Journal of Clinical and Diagnostic Research iron deficiency anaemia protein c deficiency protein s deficiency rivaroxaban thrombophilia profile |
| title | Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report |
| title_full | Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report |
| title_fullStr | Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report |
| title_full_unstemmed | Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report |
| title_short | Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report |
| title_sort | deep vein thrombosis and pulmonary embolism secondary to thrombophilic disorder a case report |
| topic | iron deficiency anaemia protein c deficiency protein s deficiency rivaroxaban thrombophilia profile |
| url | https://jcdr.net/articles/PDF/20563/74900_CE[Ra1]_F(SHU)_QC(PS_SS)_PF1(RI_SHU)_redo_PFA(SHU)_PB(RI_IS)_PN(IS).pdf |
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