Presence of triple positive driver mutations in JAK2, CALR and MPL in primary myelofibrosis: a case report and literature review

Presence of triple positive driver mutations in JAK2, CALR and MPL in primary myelofibrosis: a case report and literature review

Background Primary myelofibrosis (PMF) is the most advanced subtype among the classic Philadelphia chromosomenegative myeloproliferative neoplasms (MPNs). A majority of patients carry one of three mutually-exclusive somatic driver mutations: JAK2 (60–65%), CALR (20–25%), or MPL (5%). Co-occurrence o...

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Bibliographic Details
Main Authors: Long Zhao, Hao Zhang, Juan Chen, Haizhen Ma, Bei Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Hematology
Subjects:
Driver mutations
co-occurrence
primary myelofibrosis
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2024.2402106
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