Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action

Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action

This review covers original research focused on the design, synthesis, and pharmacological evaluation of an innovative dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) loop 4 bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106). Developed using a proprietary appr...

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Bibliographic Details
Main Authors: T. A. Gudasheva, P. Yu. Povarnina, A. V. Tarasyuk, V. P. Zherdev, A. D. Durnev
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2025-01-01
Series:Фармакокинетика и Фармакодинамика
Subjects:
brain-derived neurotrophic factor
bdnf
trkb
dipeptide mimetic
gsb-106
neuroprotective activity
antidepressant-like activity
Online Access:https://www.pharmacokinetica.ru/jour/article/view/433
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