Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
Postoperative cognitive dysfunction (POCD) is driven in part by microglial activation and the resulting neuroinflammatory response. Emerging evidence suggests that microRNAs regulate key inflammatory pathways in the central nervous system. In this study, we examined the role of the mmu‑miR‑125a/TRAF...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-07-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1236 |
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| author | Xu Zhiyan Zhong Kaihua Chen Weiyuan Lan Huixia Zhong Weifeng Wang XiaoHong Chen Mu Pan Bin |
| author_facet | Xu Zhiyan Zhong Kaihua Chen Weiyuan Lan Huixia Zhong Weifeng Wang XiaoHong Chen Mu Pan Bin |
| author_sort | Xu Zhiyan |
| collection | DOAJ |
| description | Postoperative cognitive dysfunction (POCD) is driven in part by microglial activation and the resulting neuroinflammatory response. Emerging evidence suggests that microRNAs regulate key inflammatory pathways in the central nervous system. In this study, we examined the role of the mmu‑miR‑125a/TRAF6 signaling axis in microglial activation under inflammatory conditions induced by lipopolysaccharide (LPS) and surgical trauma and evaluated whether dexmedetomidine (DEX) modulates this pathway to alleviate POCD. |
| format | Article |
| id | doaj-art-d68b2a1c11274af38b19a591bcd1b2f3 |
| institution | Kabale University |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-d68b2a1c11274af38b19a591bcd1b2f32025-08-20T03:34:31ZengDe GruyterOpen Medicine2391-54632025-07-01201480910.1515/med-2025-1236Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axisXu Zhiyan0Zhong Kaihua1Chen Weiyuan2Lan Huixia3Zhong Weifeng4Wang XiaoHong5Chen Mu6Pan Bin7Meizhou People’s Hospital (Meizhou Academy of Medical Sciences), Meizhou, ChinaMeizhou People’s Hospital (Meizhou Academy of Medical Sciences), Meizhou, ChinaMeizhou People’s Hospital (Meizhou Academy of Medical Sciences), Meizhou, ChinaMeizhou People’s Hospital (Meizhou Academy of Medical Sciences), Meizhou, ChinaDepartment of Urology, Guangzhou Twelfth People’s Hospital, Guangzhou, 510620, ChinaDepartment of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, ChinaDepartment of Respiratory Medicine, Guangzhou Eighth People’s Hospital, Guangzhou, 510060, ChinaDepartment of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, ChinaPostoperative cognitive dysfunction (POCD) is driven in part by microglial activation and the resulting neuroinflammatory response. Emerging evidence suggests that microRNAs regulate key inflammatory pathways in the central nervous system. In this study, we examined the role of the mmu‑miR‑125a/TRAF6 signaling axis in microglial activation under inflammatory conditions induced by lipopolysaccharide (LPS) and surgical trauma and evaluated whether dexmedetomidine (DEX) modulates this pathway to alleviate POCD.https://doi.org/10.1515/med-2025-1236pocddexmedetomidinemir-125atraf6microglial activation |
| spellingShingle | Xu Zhiyan Zhong Kaihua Chen Weiyuan Lan Huixia Zhong Weifeng Wang XiaoHong Chen Mu Pan Bin Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis Open Medicine pocd dexmedetomidine mir-125a traf6 microglial activation |
| title | Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis |
| title_full | Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis |
| title_fullStr | Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis |
| title_full_unstemmed | Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis |
| title_short | Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis |
| title_sort | dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu mirna 125 traf6 signaling axis |
| topic | pocd dexmedetomidine mir-125a traf6 microglial activation |
| url | https://doi.org/10.1515/med-2025-1236 |
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