Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis
Abstract Recent advancements in single‐molecule methods have not only made it possible to obtain precise measurements for complex biological processes but also to produce simple mathematical models for intricate biochemical mechanisms, which would otherwise be speculative. These developments have st...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Online Access: | https://doi.org/10.1002/VIW.20240018 |
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| author | Asad Ullah Neelam Mabood Mujib Ullah Mohsin Shafi Muhammad Maqbool |
| author_facet | Asad Ullah Neelam Mabood Mujib Ullah Mohsin Shafi Muhammad Maqbool |
| author_sort | Asad Ullah |
| collection | DOAJ |
| description | Abstract Recent advancements in single‐molecule methods have not only made it possible to obtain precise measurements for complex biological processes but also to produce simple mathematical models for intricate biochemical mechanisms, which would otherwise be speculative. These developments have strengthened our ability to respond through mathematical modeling to concepts of protein‒protein and protein‒DNA interactions on a nanometer level and address‐related questions. In this article, we examine an intriguing biological phenomenon in which a protein and an enzyme co‐jointly encounter carcinogenic adducts during transcription. We are focusing mainly on the dysregulation of the protein involved and the possible consequences that may arise. By providing a quantum mechanical model, we have demonstrated that the presence of carcinogenic adducts in a transcriptional bubble deregulates the protein that could cause lethal mutations. Next, we present a case study to explore carcinogenesis by suggesting an alternative experimental design. Our quantum mechanical model emphasizes the use of a quantized energies approach for specific mechanisms within the living cells. Radiation‐induced carcinogenicity can be prevented if radiation interacting with tissue is not given the energies that satisfy the quantization conditions. |
| format | Article |
| id | doaj-art-d688a2defb494beb8f8c7b085012fc08 |
| institution | OA Journals |
| issn | 2688-3988 2688-268X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj-art-d688a2defb494beb8f8c7b085012fc082025-08-20T02:17:57ZengWileyView2688-39882688-268X2024-10-0155n/an/a10.1002/VIW.20240018Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesisAsad Ullah0Neelam Mabood1Mujib Ullah2Mohsin Shafi3Muhammad Maqbool4Department of Biochemistry University of Alberta Edmonton Alberta CanadaDepartment of Pediatrics Faculty of Medicine & Dentistry University of Alberta Edmonton Alberta CanadaDepartment of Immunology and Transplantation, School of Medicine Stanford University Stanford California USAAnser Advisory Santa Ana California USAHealth Physics Program, Department of Clinical & Diagnostic Sciences The University of Alabama at Birmingham Birmingham Alabama USAAbstract Recent advancements in single‐molecule methods have not only made it possible to obtain precise measurements for complex biological processes but also to produce simple mathematical models for intricate biochemical mechanisms, which would otherwise be speculative. These developments have strengthened our ability to respond through mathematical modeling to concepts of protein‒protein and protein‒DNA interactions on a nanometer level and address‐related questions. In this article, we examine an intriguing biological phenomenon in which a protein and an enzyme co‐jointly encounter carcinogenic adducts during transcription. We are focusing mainly on the dysregulation of the protein involved and the possible consequences that may arise. By providing a quantum mechanical model, we have demonstrated that the presence of carcinogenic adducts in a transcriptional bubble deregulates the protein that could cause lethal mutations. Next, we present a case study to explore carcinogenesis by suggesting an alternative experimental design. Our quantum mechanical model emphasizes the use of a quantized energies approach for specific mechanisms within the living cells. Radiation‐induced carcinogenicity can be prevented if radiation interacting with tissue is not given the energies that satisfy the quantization conditions.https://doi.org/10.1002/VIW.20240018activation‐induced cytidine deaminasecarcinogensquantum mechanical modelingradiation‐induced cancersingle‐molecule methodsdevelopments |
| spellingShingle | Asad Ullah Neelam Mabood Mujib Ullah Mohsin Shafi Muhammad Maqbool Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis View activation‐induced cytidine deaminase carcinogens quantum mechanical modeling radiation‐induced cancer single‐molecule methods developments |
| title | Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis |
| title_full | Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis |
| title_fullStr | Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis |
| title_full_unstemmed | Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis |
| title_short | Single‐molecule methods, activation‐induced cytidine deaminase, and quantum mechanical approach to explore and prevent carcinogenesis |
| title_sort | single molecule methods activation induced cytidine deaminase and quantum mechanical approach to explore and prevent carcinogenesis |
| topic | activation‐induced cytidine deaminase carcinogens quantum mechanical modeling radiation‐induced cancer single‐molecule methods developments |
| url | https://doi.org/10.1002/VIW.20240018 |
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