Amygdala Plasticity and Pain
The amygdala is a limbic brain region that plays a key role in emotional processing, neuropsychiatric disorders, and the emotional-affective dimension of pain. Preclinical and clinical studies have identified amygdala hyperactivity as well as impairment of cortical control mechanisms in pain states....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2017/8296501 |
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| _version_ | 1850174970141868032 |
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| author | Jeremy M. Thompson Volker Neugebauer |
| author_facet | Jeremy M. Thompson Volker Neugebauer |
| author_sort | Jeremy M. Thompson |
| collection | DOAJ |
| description | The amygdala is a limbic brain region that plays a key role in emotional processing, neuropsychiatric disorders, and the emotional-affective dimension of pain. Preclinical and clinical studies have identified amygdala hyperactivity as well as impairment of cortical control mechanisms in pain states. Hyperactivity of basolateral amygdala (BLA) neurons generates enhanced feedforward inhibition and deactivation of the medial prefrontal cortex (mPFC), resulting in pain-related cognitive deficits. The mPFC sends excitatory projections to GABAergic neurons in the intercalated cell mass (ITC) in the amygdala, which project to the laterocapsular division of the central nucleus of the amygdala (CeLC; output nucleus) and serve gating functions for amygdala output. Impairment of these cortical control mechanisms allows the development of amygdala pain plasticity. Mechanisms of abnormal amygdala activity in pain with particular focus on loss of cortical control mechanisms as well as new strategies to correct pain-related amygdala dysfunction will be discussed in the present review. |
| format | Article |
| id | doaj-art-d6856fa0afa24cde9647d8f235ba6d0b |
| institution | OA Journals |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-d6856fa0afa24cde9647d8f235ba6d0b2025-08-20T02:19:33ZengWileyPain Research and Management1203-67651918-15232017-01-01201710.1155/2017/82965018296501Amygdala Plasticity and PainJeremy M. Thompson0Volker Neugebauer1Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX, USADepartment of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX, USAThe amygdala is a limbic brain region that plays a key role in emotional processing, neuropsychiatric disorders, and the emotional-affective dimension of pain. Preclinical and clinical studies have identified amygdala hyperactivity as well as impairment of cortical control mechanisms in pain states. Hyperactivity of basolateral amygdala (BLA) neurons generates enhanced feedforward inhibition and deactivation of the medial prefrontal cortex (mPFC), resulting in pain-related cognitive deficits. The mPFC sends excitatory projections to GABAergic neurons in the intercalated cell mass (ITC) in the amygdala, which project to the laterocapsular division of the central nucleus of the amygdala (CeLC; output nucleus) and serve gating functions for amygdala output. Impairment of these cortical control mechanisms allows the development of amygdala pain plasticity. Mechanisms of abnormal amygdala activity in pain with particular focus on loss of cortical control mechanisms as well as new strategies to correct pain-related amygdala dysfunction will be discussed in the present review.http://dx.doi.org/10.1155/2017/8296501 |
| spellingShingle | Jeremy M. Thompson Volker Neugebauer Amygdala Plasticity and Pain Pain Research and Management |
| title | Amygdala Plasticity and Pain |
| title_full | Amygdala Plasticity and Pain |
| title_fullStr | Amygdala Plasticity and Pain |
| title_full_unstemmed | Amygdala Plasticity and Pain |
| title_short | Amygdala Plasticity and Pain |
| title_sort | amygdala plasticity and pain |
| url | http://dx.doi.org/10.1155/2017/8296501 |
| work_keys_str_mv | AT jeremymthompson amygdalaplasticityandpain AT volkerneugebauer amygdalaplasticityandpain |