Short course chemotherapy in children suffering from drug resistant tuberculosis
The objective: to study the effect of short course chemotherapy regimens on treatment outcomes in children with drug resistant tuberculosis.Subjects and methods. In 2017-2019, 31 children at the age from 3 to 17 years old, received short course chemotherapy which lasted for 12-15 months. Children of...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2021-03-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1509 |
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| author | N. I. Klevno V. A. Аksenova A. V. Kazakov E. B. Kovalevskaya |
| author_facet | N. I. Klevno V. A. Аksenova A. V. Kazakov E. B. Kovalevskaya |
| author_sort | N. I. Klevno |
| collection | DOAJ |
| description | The objective: to study the effect of short course chemotherapy regimens on treatment outcomes in children with drug resistant tuberculosis.Subjects and methods. In 2017-2019, 31 children at the age from 3 to 17 years old, received short course chemotherapy which lasted for 12-15 months. Children of both genders were enrolled in the study, they all were new pulmonary tuberculosis cases with multiple drug resistance or at risk of MDR, with no history of previous treatment with reserve anti-tuberculosis drugs, and without severe concomitant diseases. Before the treatment was prescribed, all children underwent lung computed tomography additionally to general clinical and laboratory tests.Results. The chemotherapy regimen for each child consisted of 4-6 drugs selected individually with the consideration of resistance pattern of the child or suspected index case. In all cases, the combination of drugs included fluoroquinolones (levofloxacin or moxifloxacin). Amikacin (67.7%), aminosalicylic acid (80.6%) and prothionamide (74.2%) were frequently prescribed. 54.8% of children received pyrazinamide and 48.4% – cycloserine. Given the limited lesions, only 16.1% of children received linezolid and 9.7% of children received bedaquiline. The main chemotherapy course made 13.2 ± 0.5 months (from 12 to 15 months depending on the form of tuberculosis and changes during treatment). The duration of the intensive phase made 4.8 ± 0.3 on the average. 2 (6.5 ± 4.4%) of 31 children developed adverse events requiring the cancellation of the drugs causing them.Conclusion. This study has demonstrated satisfactory tolerability and good efficacy of these short course regimens for treatment of multiple drug resistant tuberculosis. No relapses of tuberculosis were reported. |
| format | Article |
| id | doaj-art-d682a2d5850b463488c73b6a6b3d25f1 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2021-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-d682a2d5850b463488c73b6a6b3d25f12025-08-20T02:16:01ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062021-03-01992343910.21292/2075-1230-2021-99-2-34-391506Short course chemotherapy in children suffering from drug resistant tuberculosisN. I. Klevno0V. A. Аksenova1A. V. Kazakov2E. B. Kovalevskaya3National Medical Research Center of Phthisiopulmonology and Infectious DiseasesNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesThe objective: to study the effect of short course chemotherapy regimens on treatment outcomes in children with drug resistant tuberculosis.Subjects and methods. In 2017-2019, 31 children at the age from 3 to 17 years old, received short course chemotherapy which lasted for 12-15 months. Children of both genders were enrolled in the study, they all were new pulmonary tuberculosis cases with multiple drug resistance or at risk of MDR, with no history of previous treatment with reserve anti-tuberculosis drugs, and without severe concomitant diseases. Before the treatment was prescribed, all children underwent lung computed tomography additionally to general clinical and laboratory tests.Results. The chemotherapy regimen for each child consisted of 4-6 drugs selected individually with the consideration of resistance pattern of the child or suspected index case. In all cases, the combination of drugs included fluoroquinolones (levofloxacin or moxifloxacin). Amikacin (67.7%), aminosalicylic acid (80.6%) and prothionamide (74.2%) were frequently prescribed. 54.8% of children received pyrazinamide and 48.4% – cycloserine. Given the limited lesions, only 16.1% of children received linezolid and 9.7% of children received bedaquiline. The main chemotherapy course made 13.2 ± 0.5 months (from 12 to 15 months depending on the form of tuberculosis and changes during treatment). The duration of the intensive phase made 4.8 ± 0.3 on the average. 2 (6.5 ± 4.4%) of 31 children developed adverse events requiring the cancellation of the drugs causing them.Conclusion. This study has demonstrated satisfactory tolerability and good efficacy of these short course regimens for treatment of multiple drug resistant tuberculosis. No relapses of tuberculosis were reported.https://www.tibl-journal.com/jour/article/view/1509mdr tuberculosis in childrenchemotherapyshort course |
| spellingShingle | N. I. Klevno V. A. Аksenova A. V. Kazakov E. B. Kovalevskaya Short course chemotherapy in children suffering from drug resistant tuberculosis Туберкулез и болезни лёгких mdr tuberculosis in children chemotherapy short course |
| title | Short course chemotherapy in children suffering from drug resistant tuberculosis |
| title_full | Short course chemotherapy in children suffering from drug resistant tuberculosis |
| title_fullStr | Short course chemotherapy in children suffering from drug resistant tuberculosis |
| title_full_unstemmed | Short course chemotherapy in children suffering from drug resistant tuberculosis |
| title_short | Short course chemotherapy in children suffering from drug resistant tuberculosis |
| title_sort | short course chemotherapy in children suffering from drug resistant tuberculosis |
| topic | mdr tuberculosis in children chemotherapy short course |
| url | https://www.tibl-journal.com/jour/article/view/1509 |
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