Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China
Introduction: Coxsackievirus A10 (CVA10) is a non-enveloped, positive-sense single-stranded RNA virus classified within the Enterovirus genus in the Picornaviridae family. It is among the pathogens that can cause hand, foot and mouth disease. This study aimed to analyze the temporal and spatial dis...
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The Journal of Infection in Developing Countries
2024-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/18411 |
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| author | Hua Wang Wenhong Wang Guoqing Chen Chuanjie Hu Shengjie Chen Lingxiang Mao Hongxing Shen |
| author_facet | Hua Wang Wenhong Wang Guoqing Chen Chuanjie Hu Shengjie Chen Lingxiang Mao Hongxing Shen |
| author_sort | Hua Wang |
| collection | DOAJ |
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Introduction: Coxsackievirus A10 (CVA10) is a non-enveloped, positive-sense single-stranded RNA virus classified within the Enterovirus genus in the Picornaviridae family. It is among the pathogens that can cause hand, foot and mouth disease. This study aimed to analyze the temporal and spatial distribution of CVA10 in China to understand its epidemiological characteristics of CVA10.
Methodology: We collected the VP1 sequences of CVA10 from January 1, 2004, to December 31, 2019, from the GenBank database and created the global map using MapChart. We selected 56 known CVA10 genotype sequences. Then, MEGA6.06 was used to construct a phylogenetic tree with the collected gene sequences and the known reference sequences for comparative analysis to assess the distribution of CVA10 genotypes in different countries between 2004 and 2019.
Results: CVA10 has been widely detected or reported globally. In China, the prevalent genotype of CVA10 was mainly genotype B before 2008 and genotype C after 2009. In other countries, the prevalence of genotype D was dominant, followed by genotypes C and F, and the prevalence of CVA10 varied from continent to continent.
Conclusions: Monitoring CVA10 genotypes or evolutionary branches should be strengthened, and the study of epidemic genotype characteristics should be enhanced. This will serve as a basis for further research and development of monovalent CVA10 or polyvalent vaccines designed for effective disease prevention.
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| format | Article |
| id | doaj-art-d679a82012044f4ca31e4ed9f951cbc4 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-d679a82012044f4ca31e4ed9f951cbc42025-08-20T02:57:04ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-07-01180710.3855/jidc.18411Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from ChinaHua Wang0Wenhong Wang1Guoqing Chen2Chuanjie Hu3Shengjie Chen4Lingxiang Mao5Hongxing Shen6Department of Laboratory Medicine, Medical School, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Laboratory Medicine, Medical School, Jiangsu University, Zhenjiang, Jiangsu, ChinaYancheng Municipal Center for Disease Control and Prevention, Yancheng, Jiangsu, ChinaDepartment of Laboratory Medicine, Medical School, Jiangsu University, Zhenjiang, Jiangsu, ChinaCardiothoracic Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaAffiliated Kunshan Hospital of Jiangsu University, Kunshan, ChinaDepartment of Laboratory Medicine, Medical School, Jiangsu University, Zhenjiang, Jiangsu, China Introduction: Coxsackievirus A10 (CVA10) is a non-enveloped, positive-sense single-stranded RNA virus classified within the Enterovirus genus in the Picornaviridae family. It is among the pathogens that can cause hand, foot and mouth disease. This study aimed to analyze the temporal and spatial distribution of CVA10 in China to understand its epidemiological characteristics of CVA10. Methodology: We collected the VP1 sequences of CVA10 from January 1, 2004, to December 31, 2019, from the GenBank database and created the global map using MapChart. We selected 56 known CVA10 genotype sequences. Then, MEGA6.06 was used to construct a phylogenetic tree with the collected gene sequences and the known reference sequences for comparative analysis to assess the distribution of CVA10 genotypes in different countries between 2004 and 2019. Results: CVA10 has been widely detected or reported globally. In China, the prevalent genotype of CVA10 was mainly genotype B before 2008 and genotype C after 2009. In other countries, the prevalence of genotype D was dominant, followed by genotypes C and F, and the prevalence of CVA10 varied from continent to continent. Conclusions: Monitoring CVA10 genotypes or evolutionary branches should be strengthened, and the study of epidemic genotype characteristics should be enhanced. This will serve as a basis for further research and development of monovalent CVA10 or polyvalent vaccines designed for effective disease prevention. https://jidc.org/index.php/journal/article/view/18411Coxsackievirus A10hand-foot-mouth diseaseVP1 |
| spellingShingle | Hua Wang Wenhong Wang Guoqing Chen Chuanjie Hu Shengjie Chen Lingxiang Mao Hongxing Shen Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China Journal of Infection in Developing Countries Coxsackievirus A10 hand-foot-mouth disease VP1 |
| title | Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China |
| title_full | Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China |
| title_fullStr | Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China |
| title_full_unstemmed | Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China |
| title_short | Molecular characteristics of the structure protein VP1 in Coxsackievirus A10 Isolates from China |
| title_sort | molecular characteristics of the structure protein vp1 in coxsackievirus a10 isolates from china |
| topic | Coxsackievirus A10 hand-foot-mouth disease VP1 |
| url | https://jidc.org/index.php/journal/article/view/18411 |
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