Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis
Diagnosing Alzheimer’s disease (AD) remains a significant challenge due to its multifactorial nature and the limitations of traditional diagnostic methods, such as clinical assessments and neuroimaging, which often lack the specificity and sensitivity required for early detection. The urgent need fo...
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MDPI AG
2025-06-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/13/6/220 |
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| author | Stephen Rathinaraj Benjamin Fábio de Lima Paulo Iury Gomes Nunes Rosa Fireman Dutra Geanne Matos de Andrade Reinaldo B. Oriá |
| author_facet | Stephen Rathinaraj Benjamin Fábio de Lima Paulo Iury Gomes Nunes Rosa Fireman Dutra Geanne Matos de Andrade Reinaldo B. Oriá |
| author_sort | Stephen Rathinaraj Benjamin |
| collection | DOAJ |
| description | Diagnosing Alzheimer’s disease (AD) remains a significant challenge due to its multifactorial nature and the limitations of traditional diagnostic methods, such as clinical assessments and neuroimaging, which often lack the specificity and sensitivity required for early detection. The urgent need for innovative diagnostic tools is further underscored by the potential of early intervention to improve treatment outcomes and slow disease progression. Recent advancements in biosensing technologies offer promising solutions for precise and non-invasive AD detection. Electrochemical and optical biosensors, in particular, provide high sensitivity, specificity, and real-time detection capabilities, making them valuable for identifying key biomarkers, including amyloid-β (Aβ) peptides and tau proteins. Additionally, integrating these biosensors with nanomaterials enhances their performance, stability, and detection limits, enabling improved diagnostic accuracy. Beyond nanomaterial-based sensors, emerging innovations in microfluidics, surface plasmon resonance (SPR), and artificial intelligence-assisted biosensing further contribute to the development of next-generation AD diagnostics. This review provides a comprehensive analysis of the latest advancements in biosensing technologies for AD, highlighting their mechanisms, advantages, and future perspectives in detecting biomarkers from biological fluids. |
| format | Article |
| id | doaj-art-d6792c4e90ae494782e6709f7a4f2b8a |
| institution | Kabale University |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Chemosensors |
| spelling | doaj-art-d6792c4e90ae494782e6709f7a4f2b8a2025-08-20T03:27:18ZengMDPI AGChemosensors2227-90402025-06-0113622010.3390/chemosensors13060220Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease DiagnosisStephen Rathinaraj Benjamin0Fábio de Lima1Paulo Iury Gomes Nunes2Rosa Fireman Dutra3Geanne Matos de Andrade4Reinaldo B. Oriá5Neuroscience and Behavior Laboratory, Department of Physiology and Pharmacology, Drug Research and Development Center (NPDM), Federal University of Ceará (UFC), Fortaleza 60430-270, BrazilPostgraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, BrazilPostgraduate Program in Medical Sciences (PPGCM), School of Medicine, Federal University of Ceará (UFC), Fortaleza 60430-140, BrazilBiomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco (UFPE), Recife 50670-90, BrazilNeuroscience and Behavior Laboratory, Department of Physiology and Pharmacology, Drug Research and Development Center (NPDM), Federal University of Ceará (UFC), Fortaleza 60430-270, BrazilLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology, Institute of Biomedicine, School of Medicine, Federal University of Ceara, Fortaleza 60430-270, BrazilDiagnosing Alzheimer’s disease (AD) remains a significant challenge due to its multifactorial nature and the limitations of traditional diagnostic methods, such as clinical assessments and neuroimaging, which often lack the specificity and sensitivity required for early detection. The urgent need for innovative diagnostic tools is further underscored by the potential of early intervention to improve treatment outcomes and slow disease progression. Recent advancements in biosensing technologies offer promising solutions for precise and non-invasive AD detection. Electrochemical and optical biosensors, in particular, provide high sensitivity, specificity, and real-time detection capabilities, making them valuable for identifying key biomarkers, including amyloid-β (Aβ) peptides and tau proteins. Additionally, integrating these biosensors with nanomaterials enhances their performance, stability, and detection limits, enabling improved diagnostic accuracy. Beyond nanomaterial-based sensors, emerging innovations in microfluidics, surface plasmon resonance (SPR), and artificial intelligence-assisted biosensing further contribute to the development of next-generation AD diagnostics. This review provides a comprehensive analysis of the latest advancements in biosensing technologies for AD, highlighting their mechanisms, advantages, and future perspectives in detecting biomarkers from biological fluids.https://www.mdpi.com/2227-9040/13/6/220Alzheimer’s disease diagnosisbiosensors for neurodegenerative diseaseselectrochemical biosensorsoptical biosensorsnanomaterials in biosensingamyloid-beta (Aβ) detection |
| spellingShingle | Stephen Rathinaraj Benjamin Fábio de Lima Paulo Iury Gomes Nunes Rosa Fireman Dutra Geanne Matos de Andrade Reinaldo B. Oriá Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis Chemosensors Alzheimer’s disease diagnosis biosensors for neurodegenerative diseases electrochemical biosensors optical biosensors nanomaterials in biosensing amyloid-beta (Aβ) detection |
| title | Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis |
| title_full | Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis |
| title_fullStr | Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis |
| title_full_unstemmed | Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis |
| title_short | Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis |
| title_sort | advanced biosensing technologies leading innovations in alzheimer s disease diagnosis |
| topic | Alzheimer’s disease diagnosis biosensors for neurodegenerative diseases electrochemical biosensors optical biosensors nanomaterials in biosensing amyloid-beta (Aβ) detection |
| url | https://www.mdpi.com/2227-9040/13/6/220 |
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