Early RSV infection aggravates asthma-related Th2 responses by increasing the number of CD4<sup>+</sup> TRM cells through upregulation of PLZF

Early RSV infection aggravates asthma-related Th2 responses by increasing the number of CD4<sup>+</sup> TRM cells through upregulation of PLZF

Respiratory syncytial virus (RSV) infection is correlated with the chronic pathogenesis and exacerbation of asthma. However, the mechanism remains unclear. In this study, acute and memory (Mem) asthma models with early RSV infection are established to explore the persistence of the effects of RSV in...

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Bibliographic Details
Main Authors: Zhang Meng, Sha Jiafeng, Li Na, Feng Jingjing, Shi Tianyun, Yu Yunxia, Ren Xiaoting, Mei Zhoufang, Jie Zhijun
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
asthma
respiratory syncytial virus infection
PLZF
tissue-resident memory T cell
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024220
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