Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease
Abstract To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), the most prevalent pathological condition in human medicine, is induced by coronary art...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04193-w |
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| author | Parisa Hassanpour Fatemeh Sadeghsoltani Solmaz Saghebasl Safieh Boroumand Parisa Khanicheragh Seyed Hossein Ahmadi Tafti Reza Rahbarghazi Mohammad Rahmati |
| author_facet | Parisa Hassanpour Fatemeh Sadeghsoltani Solmaz Saghebasl Safieh Boroumand Parisa Khanicheragh Seyed Hossein Ahmadi Tafti Reza Rahbarghazi Mohammad Rahmati |
| author_sort | Parisa Hassanpour |
| collection | DOAJ |
| description | Abstract To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), the most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within the myocardium. Data associated with the pro-angiogenic activity of mitochondria have not been completely elucidated in terms of cardiac tissue regeneration. Here, we aimed to highlight the recent studies and advantages related to the application of mitochondrial mass in the ischemic myocardium. How and by which mechanisms, mitochondria can reduce aberrant myocardial tissue remodeling via different pathways such as angiogenesis and de novo blood formation was discussed in detail. We hope that data from the current review article help us understand the molecular and cellular mechanisms by which transplanted mitochondria exert their regenerative properties in the ischemic myocardium. |
| format | Article |
| id | doaj-art-d67628f214494698a4359dfd41618f45 |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-d67628f214494698a4359dfd41618f452025-02-09T12:15:43ZengBMCStem Cell Research & Therapy1757-65122025-02-0116111710.1186/s13287-025-04193-wMitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart diseaseParisa Hassanpour0Fatemeh Sadeghsoltani1Solmaz Saghebasl2Safieh Boroumand3Parisa Khanicheragh4Seyed Hossein Ahmadi Tafti5Reza Rahbarghazi6Mohammad Rahmati7Stem Cell Research Center, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesResearch Center for Advanced Technologies In Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical SciencesStudent Research Center, Tabriz University of Medical SciencesResearch Center for Advanced Technologies In Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesAbstract To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), the most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within the myocardium. Data associated with the pro-angiogenic activity of mitochondria have not been completely elucidated in terms of cardiac tissue regeneration. Here, we aimed to highlight the recent studies and advantages related to the application of mitochondrial mass in the ischemic myocardium. How and by which mechanisms, mitochondria can reduce aberrant myocardial tissue remodeling via different pathways such as angiogenesis and de novo blood formation was discussed in detail. We hope that data from the current review article help us understand the molecular and cellular mechanisms by which transplanted mitochondria exert their regenerative properties in the ischemic myocardium.https://doi.org/10.1186/s13287-025-04193-wIschemic heart diseaseMitochondrial transplantationCardiac tissue regenerationAngiogenesis |
| spellingShingle | Parisa Hassanpour Fatemeh Sadeghsoltani Solmaz Saghebasl Safieh Boroumand Parisa Khanicheragh Seyed Hossein Ahmadi Tafti Reza Rahbarghazi Mohammad Rahmati Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease Stem Cell Research & Therapy Ischemic heart disease Mitochondrial transplantation Cardiac tissue regeneration Angiogenesis |
| title | Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease |
| title_full | Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease |
| title_fullStr | Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease |
| title_full_unstemmed | Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease |
| title_short | Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease |
| title_sort | mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease |
| topic | Ischemic heart disease Mitochondrial transplantation Cardiac tissue regeneration Angiogenesis |
| url | https://doi.org/10.1186/s13287-025-04193-w |
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