The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG
ABSTRACT Covalent functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows low toxicity compared to its raw form. H...
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| Format: | Article |
| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2019-07-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/837 |
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| author | Jaqueline Jamara Souza Soares Raynara Maria Silva Jacovone Paulo SOUZA Santos Márcio Henrique Zaim Dalva Lucia Araújo Faria Solange Kazumi Sakata |
| author_facet | Jaqueline Jamara Souza Soares Raynara Maria Silva Jacovone Paulo SOUZA Santos Márcio Henrique Zaim Dalva Lucia Araújo Faria Solange Kazumi Sakata |
| author_sort | Jaqueline Jamara Souza Soares |
| collection | DOAJ |
| description | ABSTRACT
Covalent functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows low toxicity compared to its raw form. However, must be sterilized prior to use in medical devices, and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, lower energy consumption, and less environmental pollution. In this work the effects of gamma radiation on GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with doses (15, 25, 35 and 50 kGy) that have been used to sterilize medical devices and at rate dose 7.3 kGy.h-1 were evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that gamma radiation up to 50 kGy did not cause any defects on the nanomaterials. |
| format | Article |
| id | doaj-art-d67264cb5a4b48cabcc967f740fc9c1e |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-d67264cb5a4b48cabcc967f740fc9c1e2025-08-20T03:27:36ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122019-07-017310.15392/bjrs.v7i3.837655The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEGJaqueline Jamara Souza Soares0Raynara Maria Silva Jacovone1Paulo SOUZA Santos2Márcio Henrique Zaim3Dalva Lucia Araújo Faria4Solange Kazumi Sakata5IPEN - Nuclear and Energy Research InstituteIPEN - Nuclear and Energy Research InstituteIPEN - Nuclear and Energy Research InstituteUniversity of São PauloUniversity of São PauloIPEN - Nuclear and Energy Research InstituteABSTRACT Covalent functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows low toxicity compared to its raw form. However, must be sterilized prior to use in medical devices, and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, lower energy consumption, and less environmental pollution. In this work the effects of gamma radiation on GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with doses (15, 25, 35 and 50 kGy) that have been used to sterilize medical devices and at rate dose 7.3 kGy.h-1 were evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that gamma radiation up to 50 kGy did not cause any defects on the nanomaterials.https://bjrs.org.br/revista/index.php/REVISTA/article/view/837functionalizationnanocompositegraphene oxide. |
| spellingShingle | Jaqueline Jamara Souza Soares Raynara Maria Silva Jacovone Paulo SOUZA Santos Márcio Henrique Zaim Dalva Lucia Araújo Faria Solange Kazumi Sakata The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG Brazilian Journal of Radiation Sciences functionalization nanocomposite graphene oxide. |
| title | The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG |
| title_full | The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG |
| title_fullStr | The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG |
| title_full_unstemmed | The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG |
| title_short | The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG |
| title_sort | effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino peg |
| topic | functionalization nanocomposite graphene oxide. |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/837 |
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