Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM
Abstract Background Voxel-based morphometry (VBM) reveals diverse alterations in gray matter volume in acute lymphoblastic leukemia (ALL) patients after chemotherapy. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize findings from e...
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BMC
2025-04-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02461-2 |
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| author | Xuelian Zong Huiping Liu Xiaoyun Zhao |
| author_facet | Xuelian Zong Huiping Liu Xiaoyun Zhao |
| author_sort | Xuelian Zong |
| collection | DOAJ |
| description | Abstract Background Voxel-based morphometry (VBM) reveals diverse alterations in gray matter volume in acute lymphoblastic leukemia (ALL) patients after chemotherapy. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize findings from existing VBM studies and identify consistent patterns of altered gray matter volume in ALL patients post-chemotherapy. Materials and methods A systematic search was conducted across PubMed, Web of Knowledge, Embase, Google Scholar, and CNKI for VBM studies that compared ALL patients post-chemotherapy with healthy controls (HCs) up to April 1, 2024. Significant cluster coordinates were extracted for comprehensive analysis. Results We included 7 studies involving 143 ALL patients post-chemotherapy and 140 HCs. ALL patients who underwent chemotherapy presented decreased gray matter volume in the left caudate nucleus, left calcarine fissure/surrounding cortex, left precentral gyrus and right anterior thalamic projections. Jackknife sensitivity analysis validated the robustness of these findings. Conclusions This meta-analysis revealed consistent gray matter volume alterations in ALL patients post-chemotherapy, emphasizing the need to explore their underlying mechanisms and long-term effects on cognitive and neurological health. |
| format | Article |
| id | doaj-art-d66c8b936f64420d883f24caa8e76b0b |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-d66c8b936f64420d883f24caa8e76b0b2025-08-20T03:08:05ZengBMCEuropean Journal of Medical Research2047-783X2025-04-013011910.1186/s40001-025-02461-2Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDMXuelian Zong0Huiping Liu1Xiaoyun Zhao2Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People’S Liberation ArmyDepartment of Pediatrics, The 940th Hospital of Joint Logistics Support Force of Chinese People’S Liberation ArmyDepartment of Pediatrics, The 940th Hospital of Joint Logistics Support Force of Chinese People’S Liberation ArmyAbstract Background Voxel-based morphometry (VBM) reveals diverse alterations in gray matter volume in acute lymphoblastic leukemia (ALL) patients after chemotherapy. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize findings from existing VBM studies and identify consistent patterns of altered gray matter volume in ALL patients post-chemotherapy. Materials and methods A systematic search was conducted across PubMed, Web of Knowledge, Embase, Google Scholar, and CNKI for VBM studies that compared ALL patients post-chemotherapy with healthy controls (HCs) up to April 1, 2024. Significant cluster coordinates were extracted for comprehensive analysis. Results We included 7 studies involving 143 ALL patients post-chemotherapy and 140 HCs. ALL patients who underwent chemotherapy presented decreased gray matter volume in the left caudate nucleus, left calcarine fissure/surrounding cortex, left precentral gyrus and right anterior thalamic projections. Jackknife sensitivity analysis validated the robustness of these findings. Conclusions This meta-analysis revealed consistent gray matter volume alterations in ALL patients post-chemotherapy, emphasizing the need to explore their underlying mechanisms and long-term effects on cognitive and neurological health.https://doi.org/10.1186/s40001-025-02461-2Acute lymphoblastic leukemiaVoxel-based morphometryAES–SDMMeta-analysis |
| spellingShingle | Xuelian Zong Huiping Liu Xiaoyun Zhao Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM European Journal of Medical Research Acute lymphoblastic leukemia Voxel-based morphometry AES–SDM Meta-analysis |
| title | Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM |
| title_full | Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM |
| title_fullStr | Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM |
| title_full_unstemmed | Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM |
| title_short | Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients’ postchemotherapy via the AES–SDM |
| title_sort | meta analysis of altered gray matter volume in acute lymphoblastic leukemia patients postchemotherapy via the aes sdm |
| topic | Acute lymphoblastic leukemia Voxel-based morphometry AES–SDM Meta-analysis |
| url | https://doi.org/10.1186/s40001-025-02461-2 |
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