Alveolar bone loss is associated with oral cancer: a case-control study
BackgroundA link between chronic inflammation and malignant transformation is evident in various cancer types. Periodontitis is the most common chronic inflammatory condition in oral medicine with a proven association with systemic diseases like diabetes. Although there is scant evidence of a potent...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1569491/full |
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| author | Leah Trumet Leah Trumet Roman Fuchs Roman Fuchs Joy Backhaus Bettina Grötsch Kerstin Galler Marco Kesting Marco Kesting Manuel Weber Manuel Weber |
| author_facet | Leah Trumet Leah Trumet Roman Fuchs Roman Fuchs Joy Backhaus Bettina Grötsch Kerstin Galler Marco Kesting Marco Kesting Manuel Weber Manuel Weber |
| author_sort | Leah Trumet |
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| description | BackgroundA link between chronic inflammation and malignant transformation is evident in various cancer types. Periodontitis is the most common chronic inflammatory condition in oral medicine with a proven association with systemic diseases like diabetes. Although there is scant evidence of a potential link between periodontitis and oral cancer there is no proof for a correlation yet. We hypothesize that radiographic bone loss (RABL) as indicator of chronic periodontitis is associated with the occurrence of oral squamous cell carcinomas (OSCC).Methods206 orthopantomograms (OPTs) from a cohort of OSCC cases and controls without OSCC, both between the age of 40 and 70, were analyzed in this retrospective study. Radiographic oral health parameters like radiographic alveolar bone loss (RABL), remaining teeth as well as implants were analyzed and compared between the two groups. The analyses of the study were controlled for the impact of confounders such as diabetes, smoking of tobacco and age. Welch-test, Chi-Square-Test and a two-way Analysis of Covariance (ANCOVA) followed by a Bonferroni post-hoc test for multiple pairwise comparison were performed.ResultsSeveral statistically significant differences were identified between the two groups, with a greater than twofold prevalence of nicotine consumption among the OSCC group. Additionally, the OSCC cohort exhibited a mean age approximately 3.5 years higher and a lower number of remaining teeth compared to the control group. After eliminating the effect of these confounders, a significantly greater loss of bone mass was observed in the OSCC cohort in comparison to the control cohort.ConclusionIn consideration of the confounders, patients with OSCC had more bone loss, compared to controls. These data indicate an association between periodontitis derived chronical inflammation and the malignant transformation of oral epithelium. |
| format | Article |
| id | doaj-art-d66a8b47071242beb3bd5136637be913 |
| institution | OA Journals |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-d66a8b47071242beb3bd5136637be9132025-08-20T02:16:09ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-05-01610.3389/froh.2025.15694911569491Alveolar bone loss is associated with oral cancer: a case-control studyLeah Trumet0Leah Trumet1Roman Fuchs2Roman Fuchs3Joy Backhaus4Bettina Grötsch5Kerstin Galler6Marco Kesting7Marco Kesting8Manuel Weber9Manuel Weber10Department of Operative Dentistry and Periodontology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDeutsches Zentrum Immuntherapie (DZI) and Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDeutsches Zentrum Immuntherapie (DZI) and Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDepartment of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyInstitute of Medical Teaching and Medical Education Research, University Hospital of Würzburg, Würzburg, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDepartment of Operative Dentistry and Periodontology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDeutsches Zentrum Immuntherapie (DZI) and Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDepartment of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDeutsches Zentrum Immuntherapie (DZI) and Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDepartment of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyBackgroundA link between chronic inflammation and malignant transformation is evident in various cancer types. Periodontitis is the most common chronic inflammatory condition in oral medicine with a proven association with systemic diseases like diabetes. Although there is scant evidence of a potential link between periodontitis and oral cancer there is no proof for a correlation yet. We hypothesize that radiographic bone loss (RABL) as indicator of chronic periodontitis is associated with the occurrence of oral squamous cell carcinomas (OSCC).Methods206 orthopantomograms (OPTs) from a cohort of OSCC cases and controls without OSCC, both between the age of 40 and 70, were analyzed in this retrospective study. Radiographic oral health parameters like radiographic alveolar bone loss (RABL), remaining teeth as well as implants were analyzed and compared between the two groups. The analyses of the study were controlled for the impact of confounders such as diabetes, smoking of tobacco and age. Welch-test, Chi-Square-Test and a two-way Analysis of Covariance (ANCOVA) followed by a Bonferroni post-hoc test for multiple pairwise comparison were performed.ResultsSeveral statistically significant differences were identified between the two groups, with a greater than twofold prevalence of nicotine consumption among the OSCC group. Additionally, the OSCC cohort exhibited a mean age approximately 3.5 years higher and a lower number of remaining teeth compared to the control group. After eliminating the effect of these confounders, a significantly greater loss of bone mass was observed in the OSCC cohort in comparison to the control cohort.ConclusionIn consideration of the confounders, patients with OSCC had more bone loss, compared to controls. These data indicate an association between periodontitis derived chronical inflammation and the malignant transformation of oral epithelium.https://www.frontiersin.org/articles/10.3389/froh.2025.1569491/fullOSCCperiodontitisorthopantomogramoral medicineoral healthbone loss |
| spellingShingle | Leah Trumet Leah Trumet Roman Fuchs Roman Fuchs Joy Backhaus Bettina Grötsch Kerstin Galler Marco Kesting Marco Kesting Manuel Weber Manuel Weber Alveolar bone loss is associated with oral cancer: a case-control study Frontiers in Oral Health OSCC periodontitis orthopantomogram oral medicine oral health bone loss |
| title | Alveolar bone loss is associated with oral cancer: a case-control study |
| title_full | Alveolar bone loss is associated with oral cancer: a case-control study |
| title_fullStr | Alveolar bone loss is associated with oral cancer: a case-control study |
| title_full_unstemmed | Alveolar bone loss is associated with oral cancer: a case-control study |
| title_short | Alveolar bone loss is associated with oral cancer: a case-control study |
| title_sort | alveolar bone loss is associated with oral cancer a case control study |
| topic | OSCC periodontitis orthopantomogram oral medicine oral health bone loss |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1569491/full |
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