Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study
BackgroundCognitive impairment is a common dysfunction following stroke, significantly affecting patients’ quality of life. Studies suggest that post-stroke cognitive impairment (PSCI) may be related to neural activity in specific brain regions. However, the neural mechanisms remain to be further ex...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1501082/full |
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| author | Kaiyue Han Kaiyue Han Linghui Dong Linghui Dong Xingxing Liao Xingxing Liao Xingxing Liao Junzi Long Junzi Long Junzi Long Jiarou Chen Jiarou Chen Haitao Lu Haitao Lu Hao Zhang Hao Zhang Hao Zhang Hao Zhang |
| author_facet | Kaiyue Han Kaiyue Han Linghui Dong Linghui Dong Xingxing Liao Xingxing Liao Xingxing Liao Junzi Long Junzi Long Junzi Long Jiarou Chen Jiarou Chen Haitao Lu Haitao Lu Hao Zhang Hao Zhang Hao Zhang Hao Zhang |
| author_sort | Kaiyue Han |
| collection | DOAJ |
| description | BackgroundCognitive impairment is a common dysfunction following stroke, significantly affecting patients’ quality of life. Studies suggest that post-stroke cognitive impairment (PSCI) may be related to neural activity in specific brain regions. However, the neural mechanisms remain to be further explored. This study aimed to investigate the alterations in brain function in patients with PSCI.MethodsThis was a case–control study. Thirty patients with PSCI, thirty with non-PSCI (NPSCI), and thirty age- and gender-matched healthy controls (HCs) were selected in a 1:1:1 ratio. Resting-state functional magnetic resonance imaging (rs-fMRI) were acquired from all participants to study the potential neural mechanisms of PSCI patients by comparing the differences in fractional amplitude of low-frequency fluctuation (fALFF), Kendall’s coefficient of concordance-regional homogeneity (KCC-ReHo), and seed-based functional connectivity (FC). Additionally, the Montreal Cognitive Assessment (MoCA) scores of PSCI patients were collected, and Pearson correlation was used to analyze the correlation between functional indicators and cognitive performance in PSCI patients.ResultsfALFF analysis revealed that the PSCI group had decreased zfALFF values in the left caudate, right inferior temporal gyrus (ITG), anterior cingulate cortex (ACC), left putamen, and left superior temporal gyrus. In contrast, increased zfALFF values were observed in the right Cerebellum_6. KCC-ReHo analysis indicated that the PSCI group had decreased SzKCC-ReHo values in the right middle frontal gyrus (MFG) and left postcentral lobe, while increased SzKCC-ReHo values in the left cerebellum_ crus 1, and left cerebellum_4–5. Furthermore, seed-based FC analysis revealed decreased zFC values between brain regions in the PSCI group, especially between the angular gyrus and precuneus. Additionally, correlation analysis showed that the zfALFF value of ACC was positively correlated with MoCA scores in the PSCI group.ConclusionThis study demonstrated significant changes in the spontaneous neural activity intensity, regional homogeneity, and FC of multiple cognition-related brain regions in PSCI patients, shedding light on the underlying neural mechanisms of brain function in PSCI. |
| format | Article |
| id | doaj-art-d66a1e40905b420e8bc198b8090ac419 |
| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-d66a1e40905b420e8bc198b8090ac4192025-08-20T03:11:47ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.15010821501082Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging studyKaiyue Han0Kaiyue Han1Linghui Dong2Linghui Dong3Xingxing Liao4Xingxing Liao5Xingxing Liao6Junzi Long7Junzi Long8Junzi Long9Jiarou Chen10Jiarou Chen11Haitao Lu12Haitao Lu13Hao Zhang14Hao Zhang15Hao Zhang16Hao Zhang17School of Rehabilitation, Capital Medical University, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaChangping Laboratory, Beijing, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaChangping Laboratory, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaThe Second School of Medicine, Wenzhou Medical University, Wenzhou, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaBeijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaUniversity of Health and Rehabilitation Sciences, Qingdao, ChinaBackgroundCognitive impairment is a common dysfunction following stroke, significantly affecting patients’ quality of life. Studies suggest that post-stroke cognitive impairment (PSCI) may be related to neural activity in specific brain regions. However, the neural mechanisms remain to be further explored. This study aimed to investigate the alterations in brain function in patients with PSCI.MethodsThis was a case–control study. Thirty patients with PSCI, thirty with non-PSCI (NPSCI), and thirty age- and gender-matched healthy controls (HCs) were selected in a 1:1:1 ratio. Resting-state functional magnetic resonance imaging (rs-fMRI) were acquired from all participants to study the potential neural mechanisms of PSCI patients by comparing the differences in fractional amplitude of low-frequency fluctuation (fALFF), Kendall’s coefficient of concordance-regional homogeneity (KCC-ReHo), and seed-based functional connectivity (FC). Additionally, the Montreal Cognitive Assessment (MoCA) scores of PSCI patients were collected, and Pearson correlation was used to analyze the correlation between functional indicators and cognitive performance in PSCI patients.ResultsfALFF analysis revealed that the PSCI group had decreased zfALFF values in the left caudate, right inferior temporal gyrus (ITG), anterior cingulate cortex (ACC), left putamen, and left superior temporal gyrus. In contrast, increased zfALFF values were observed in the right Cerebellum_6. KCC-ReHo analysis indicated that the PSCI group had decreased SzKCC-ReHo values in the right middle frontal gyrus (MFG) and left postcentral lobe, while increased SzKCC-ReHo values in the left cerebellum_ crus 1, and left cerebellum_4–5. Furthermore, seed-based FC analysis revealed decreased zFC values between brain regions in the PSCI group, especially between the angular gyrus and precuneus. Additionally, correlation analysis showed that the zfALFF value of ACC was positively correlated with MoCA scores in the PSCI group.ConclusionThis study demonstrated significant changes in the spontaneous neural activity intensity, regional homogeneity, and FC of multiple cognition-related brain regions in PSCI patients, shedding light on the underlying neural mechanisms of brain function in PSCI.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1501082/fullstrokepost-stroke cognitive impairmentresting-state functional magnetic resonance imagingfractional amplitude of low-frequency fluctuationsregional homogeneityfunctional connectivity |
| spellingShingle | Kaiyue Han Kaiyue Han Linghui Dong Linghui Dong Xingxing Liao Xingxing Liao Xingxing Liao Junzi Long Junzi Long Junzi Long Jiarou Chen Jiarou Chen Haitao Lu Haitao Lu Hao Zhang Hao Zhang Hao Zhang Hao Zhang Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study Frontiers in Aging Neuroscience stroke post-stroke cognitive impairment resting-state functional magnetic resonance imaging fractional amplitude of low-frequency fluctuations regional homogeneity functional connectivity |
| title | Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study |
| title_full | Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study |
| title_fullStr | Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study |
| title_full_unstemmed | Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study |
| title_short | Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study |
| title_sort | alterations in brain function in patients with post stroke cognitive impairment a resting state functional magnetic resonance imaging study |
| topic | stroke post-stroke cognitive impairment resting-state functional magnetic resonance imaging fractional amplitude of low-frequency fluctuations regional homogeneity functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1501082/full |
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