Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study
Introduction: Dengue fever poses a significant public health challenge in Nepal, with increasingsevere cases requiring intensive care. Limited data exist on the clinical profile and outcomes of critically ill dengue patients in resource-limited settings. This study is aimed to characterize the clini...
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Nepal Medical Association
2025-05-01
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| Series: | Journal of Nepal Medical Association |
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| Online Access: | https://jnma.com.np/jnma/index.php/jnma/article/view/9080 |
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| author | Eliza Koirala Gopendra Prasad Deo Shital Adhikari Basanta Gauli Akriti Bajracharya |
| author_facet | Eliza Koirala Gopendra Prasad Deo Shital Adhikari Basanta Gauli Akriti Bajracharya |
| author_sort | Eliza Koirala |
| collection | DOAJ |
| description | Introduction: Dengue fever poses a significant public health challenge in Nepal, with increasingsevere cases requiring intensive care. Limited data exist on the clinical profile and outcomes of critically ill dengue patients in resource-limited settings. This study is aimed to characterize the clinical features, outcomes and complications of dengue patients admitted to a tertiary Intensive care unit in Nepal.
Methods: A prospective observational study was conducted at from August to September 2024 after ethical approval. We enrolled 104 serologically confirmed dengue patients (aged ≥16 years) admitted to the Medical Intensive care unit. Exclusion criteria included co-infections with other tropical diseases. Data on demographics, clinical presentation, laboratory parameters (including platelet counts, liver enzymes), organ dysfunction (SOFA score), and outcomes were collected. Descriptive data analysis was used to report frequency, proportion, measure of central tendency and measure of dispersion based on nature of data.
Results: The cohort (median age 41 years, 54.8% male) exhibited severe manifestations: thrombocytopenia (median platelets count 49,000/μL; IQR: 30,250–85,000 per μL), hepatic injury 86 (82.7%); median AST 176.5 U/L, ALT 208.5 U/L), and moderate organ dysfunction (median SOFA score 4). Hypertension 27 (25.96%) and diabetes 23 (22.12%) were common comorbidities. Despite 22 (21.2%) developing multi-organ dysfunction syndrome, mortality was remarkably low 1 (0.96%).
Conclusions: Dengue fever cases peak during the month of August and September in endemic areas (Chitwan and surrounding district). Mortality could be reduced in severe dengue with appropriate critical care, highlighting the need to strengthen ICU capacity in endemic regions.
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| format | Article |
| id | doaj-art-d66558459f254c2a909e341d163dc9be |
| institution | Kabale University |
| issn | 0028-2715 1815-672X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nepal Medical Association |
| record_format | Article |
| series | Journal of Nepal Medical Association |
| spelling | doaj-art-d66558459f254c2a909e341d163dc9be2025-08-20T03:46:54ZengNepal Medical AssociationJournal of Nepal Medical Association0028-27151815-672X2025-05-016328610.31729/jnma.9080Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational StudyEliza Koirala0Gopendra Prasad Deo1Shital Adhikari2Basanta Gauli3Akriti Bajracharya4Department of Critical Care Medicine, Chitwan Medical College Teaching Hospital, Bharatpur, Chitwan, NepalDepartment of Anesthesiology and Critical Care Medicine, Chitwan Medical College Teaching Hospital, Bharatpur, Chitwan, NepalDepartment of Pulmonology and Critical Care Medicine, Chitwan Medical College Teaching Hospital, Bharatpur, Chitwan, NepalDepartment of Critical Care Medicine, Chitwan Medical College Teaching Hospital, Bharatpur, Chitwan, NepalDepartment of Critical Care Medicine, Chitwan Medical College Teaching Hospital, Bharatpur, Chitwan, NepalIntroduction: Dengue fever poses a significant public health challenge in Nepal, with increasingsevere cases requiring intensive care. Limited data exist on the clinical profile and outcomes of critically ill dengue patients in resource-limited settings. This study is aimed to characterize the clinical features, outcomes and complications of dengue patients admitted to a tertiary Intensive care unit in Nepal. Methods: A prospective observational study was conducted at from August to September 2024 after ethical approval. We enrolled 104 serologically confirmed dengue patients (aged ≥16 years) admitted to the Medical Intensive care unit. Exclusion criteria included co-infections with other tropical diseases. Data on demographics, clinical presentation, laboratory parameters (including platelet counts, liver enzymes), organ dysfunction (SOFA score), and outcomes were collected. Descriptive data analysis was used to report frequency, proportion, measure of central tendency and measure of dispersion based on nature of data. Results: The cohort (median age 41 years, 54.8% male) exhibited severe manifestations: thrombocytopenia (median platelets count 49,000/μL; IQR: 30,250–85,000 per μL), hepatic injury 86 (82.7%); median AST 176.5 U/L, ALT 208.5 U/L), and moderate organ dysfunction (median SOFA score 4). Hypertension 27 (25.96%) and diabetes 23 (22.12%) were common comorbidities. Despite 22 (21.2%) developing multi-organ dysfunction syndrome, mortality was remarkably low 1 (0.96%). Conclusions: Dengue fever cases peak during the month of August and September in endemic areas (Chitwan and surrounding district). Mortality could be reduced in severe dengue with appropriate critical care, highlighting the need to strengthen ICU capacity in endemic regions. https://jnma.com.np/jnma/index.php/jnma/article/view/9080clinical profile and outcomedengue fevermedical intensive care unitmulti-organ disorderNepal |
| spellingShingle | Eliza Koirala Gopendra Prasad Deo Shital Adhikari Basanta Gauli Akriti Bajracharya Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study Journal of Nepal Medical Association clinical profile and outcome dengue fever medical intensive care unit multi-organ disorder Nepal |
| title | Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study |
| title_full | Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study |
| title_fullStr | Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study |
| title_full_unstemmed | Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study |
| title_short | Clinical profile and outcome of Dengue fever in Medical Intensive Care Unit of a Tertiary Level Hospital: An Observational Study |
| title_sort | clinical profile and outcome of dengue fever in medical intensive care unit of a tertiary level hospital an observational study |
| topic | clinical profile and outcome dengue fever medical intensive care unit multi-organ disorder Nepal |
| url | https://jnma.com.np/jnma/index.php/jnma/article/view/9080 |
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