Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study
Abstract Purpose Micro‐fragmented adipose tissue is emerging as a promising option for the treatment of various diseases including knee osteoarthritis (OA), though clinical trials are often limited by short follow‐up periods. Our aim was to evaluate the safety and clinical outcomes of an arthroscopi...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Journal of Experimental Orthopaedics |
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| Online Access: | https://doi.org/10.1002/jeo2.70144 |
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| author | Andrea Antonio Maria Bruno Giuseppe Anzillotti Massimo De Donato Marco Basso Jacopo Tamini Paolo Dupplicato Elizaveta Kon Berardo Di Matteo Enrico Arnaldi |
| author_facet | Andrea Antonio Maria Bruno Giuseppe Anzillotti Massimo De Donato Marco Basso Jacopo Tamini Paolo Dupplicato Elizaveta Kon Berardo Di Matteo Enrico Arnaldi |
| author_sort | Andrea Antonio Maria Bruno |
| collection | DOAJ |
| description | Abstract Purpose Micro‐fragmented adipose tissue is emerging as a promising option for the treatment of various diseases including knee osteoarthritis (OA), though clinical trials are often limited by short follow‐up periods. Our aim was to evaluate the safety and clinical outcomes of an arthroscopic debridement followed by a single injection of micro‐fragmented adipose tissue in patients affected by knee OA. Methods From 2016 to 2020, patients affected by knee OA were enroled. Micro‐fragmented adipose tissue was obtained through the Lipogems® kit and intraarticularly injected after an arthroscopic debridement. Visual analogue scale for pain, Tegner score, Knee Injury and Osteoarthritis Outcome score subscales variations were assessed from baseline to 3, 6, 12, 24 and 48 months of follow‐up. Results Forty‐one patients were evaluated up to 6 months of follow‐up, 39 patients up to 24 months of follow‐up and 38 patients up to 48 months of follow‐up. Three underwent knee replacement surgery during the time of the study. All the clinical scores analyzed achieved statistically significant changes up to the last follow‐up. Conclusions A single intra‐articular knee injection of micro‐fragmented adipose tissue following arthroscopic debridement is able to provide significant clinical benefits in patients affected by knee OA up to 4 years of follow‐up. The present clinical study was registered on clinicaltrials.gov (no. NCT06545266). Level of Evidence Level IV case series. |
| format | Article |
| id | doaj-art-d66470ec20fd4abdab78f48f4fcb6e95 |
| institution | DOAJ |
| issn | 2197-1153 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Experimental Orthopaedics |
| spelling | doaj-art-d66470ec20fd4abdab78f48f4fcb6e952025-08-20T03:13:07ZengWileyJournal of Experimental Orthopaedics2197-11532025-01-01121n/an/a10.1002/jeo2.70144Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical studyAndrea Antonio Maria Bruno0Giuseppe Anzillotti1Massimo De Donato2Marco Basso3Jacopo Tamini4Paolo Dupplicato5Elizaveta Kon6Berardo Di Matteo7Enrico Arnaldi8IRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyIRCCS Humanitas Research Hospital Rozzano Milan ItalyAbstract Purpose Micro‐fragmented adipose tissue is emerging as a promising option for the treatment of various diseases including knee osteoarthritis (OA), though clinical trials are often limited by short follow‐up periods. Our aim was to evaluate the safety and clinical outcomes of an arthroscopic debridement followed by a single injection of micro‐fragmented adipose tissue in patients affected by knee OA. Methods From 2016 to 2020, patients affected by knee OA were enroled. Micro‐fragmented adipose tissue was obtained through the Lipogems® kit and intraarticularly injected after an arthroscopic debridement. Visual analogue scale for pain, Tegner score, Knee Injury and Osteoarthritis Outcome score subscales variations were assessed from baseline to 3, 6, 12, 24 and 48 months of follow‐up. Results Forty‐one patients were evaluated up to 6 months of follow‐up, 39 patients up to 24 months of follow‐up and 38 patients up to 48 months of follow‐up. Three underwent knee replacement surgery during the time of the study. All the clinical scores analyzed achieved statistically significant changes up to the last follow‐up. Conclusions A single intra‐articular knee injection of micro‐fragmented adipose tissue following arthroscopic debridement is able to provide significant clinical benefits in patients affected by knee OA up to 4 years of follow‐up. The present clinical study was registered on clinicaltrials.gov (no. NCT06545266). Level of Evidence Level IV case series.https://doi.org/10.1002/jeo2.70144adipose‐derived stem cellsarthroscopykneemesenchymal stem cellsosteoarthritis |
| spellingShingle | Andrea Antonio Maria Bruno Giuseppe Anzillotti Massimo De Donato Marco Basso Jacopo Tamini Paolo Dupplicato Elizaveta Kon Berardo Di Matteo Enrico Arnaldi Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study Journal of Experimental Orthopaedics adipose‐derived stem cells arthroscopy knee mesenchymal stem cells osteoarthritis |
| title | Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study |
| title_full | Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study |
| title_fullStr | Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study |
| title_full_unstemmed | Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study |
| title_short | Arthroscopic debridement followed by intra‐articular injection of micro‐fragmented adipose tissue in patients affected by knee osteoarthritis: Clinical results up to 48 months from a prospective clinical study |
| title_sort | arthroscopic debridement followed by intra articular injection of micro fragmented adipose tissue in patients affected by knee osteoarthritis clinical results up to 48 months from a prospective clinical study |
| topic | adipose‐derived stem cells arthroscopy knee mesenchymal stem cells osteoarthritis |
| url | https://doi.org/10.1002/jeo2.70144 |
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