Anti-adherent effects of Rhizophora apiculata bark and leaf extracts and computational prediction of the effects of its compound on β-tubulin interaction in Acanthamoeba triangularis genotype 4

Anti-adherent effects of Rhizophora apiculata bark and leaf extracts and computational prediction of the effects of its compound on β-tubulin interaction in Acanthamoeba triangularis genotype 4

Background and Aim: Acanthamoeba, an opportunistic protozoan, exists widely in natural sources and can cause infections in humans and animals. The absence of effective monotherapy after the initial infection leads to chronic disease and recurrence. Tubulin protein is a vital target for design-target...

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Main Authors: Siriphorn Chimplee, Imran Sama-ae, Suthinee Sangkanu, Watcharapong Mitsuwan, Julalak Chuprom, Rachasak Boonhok, Dhrubo Ahmed Khan, Partha Biswas, Md Nazmul Hasan, Hazel Anne Tabo, Cristina C. Salibay, Polrat Wilairatana, Maria L. Pereira, Muhammad Nawaz, Ragini Bodade, Shanmuga S. Sundar, Alok K. Paul, Veeranoot Nissapatorn
Format: Article
Language:English
Published: Veterinary World 2024-12-01
Series:Veterinary World
Subjects:
acanthamoeba triangularis
anti-adherent activity
molecular docking
molecular dynamic simulation
rhizophora
tubulin
Online Access:https://www.veterinaryworld.org/Vol.17/December-2024/13.pdf
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