Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling

Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling

Tendon repair remains challenging due to its poor intrinsic healing capacity, and stem cell therapy has emerged as a promising strategy to promote tendon regeneration. Nevertheless, the inflammatory environment following acute tendon injuries disrupts stem cell differentiation, leading to unsatisfie...

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Bibliographic Details
Main Authors: Jialin Chen, Renwang Sheng, Qingyun Mo, Ludvig J. Backman, Zhiyuan Lu, Qiuzi Long, Zhixuan Chen, Zhicheng Cao, Yanan Zhang, Chuanquan Liu, Haotian Zheng, Yu Qi, Mumin Cao, Yunfeng Rui, Wei Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-02-01
Series:Bioactive Materials
Subjects:
Acute tendon injury
Stem cell therapy
NF-κB signaling
Tenogenic differentiation
Multiomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24004614
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