Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy
Context: Diabetes mellitus is a chronic, metabolic, noncommunicable disease that has attained epidemic proportions. At present, there is emerging evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Optical coherence tomography (OCT)...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Delhi Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_183_23 |
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| author | Nimisha Kaushal Neha C. Guliani Brahm P. Guliani |
| author_facet | Nimisha Kaushal Neha C. Guliani Brahm P. Guliani |
| author_sort | Nimisha Kaushal |
| collection | DOAJ |
| description | Context:
Diabetes mellitus is a chronic, metabolic, noncommunicable disease that has attained epidemic proportions. At present, there is emerging evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Optical coherence tomography (OCT) is a noninvasive technique to detect the earliest retinal changes before DR could be diagnosed on fundus examination.
Aims:
The purpose of the study was to measure retinal ganglion cell inner-plexiform layer (GC-IPL) thickness in diabetic patients with no DR or with mild nonproliferative DR (NPDR) on fundus examination.
Settings and Design:
This cross-sectional study was undertaken at a tertiary care hospital in North India over a period of 18 months.
Subjects and Methods:
Thirty-six subjects with diabetes were analyzed to study the occurrence of retinal neurodegeneration by measuring GC-IPL thickness on spectral domain-OCT (SD-OCT) examination and for comparison, GC-IPL thickness value of normal healthy nondiabetic subjects was taken (normal value taken 82.78 ± 7.01 μm).
Statistical Analysis Used:
Categorical variables were presented in number and percentage (%) and continuous variables were presented as mean ± standard deviation, median, and interquartile range. The normality of data was checked by applying the Shapiro–Wilk test and Chi-square test to check the association between two categorical variables.
Results:
There was no significant association of gender with the thickness of GC-IPL. The mean age, mean duration of diabetes, and mean glycated hemoglobin (HbA1c) levels were found to be significantly lower in diabetics with normal thickness GC-IPL as compared to those having thinner GC-IPL thickness. The mean value of average GC-IPL thickness among normal and mild NPDR fundus examinations was 86.24 μm and 75.43 μm, respectively (P = 0.000).
Conclusions:
Early detection of DR by SD-OCT can be a therapeutic window for neuroprotective treatments to reduce the damage to the retina in DR. Age, duration of diabetes, and HbA1c levels have a negative association with GC-IPL thickness in diabetics. |
| format | Article |
| id | doaj-art-d65df3a5e7ec4870ae116a85e615d386 |
| institution | OA Journals |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-d65df3a5e7ec4870ae116a85e615d3862025-08-20T01:48:54ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842024-01-01341273110.4103/DLJO.DLJO_183_23Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without RetinopathyNimisha KaushalNeha C. GulianiBrahm P. GulianiContext: Diabetes mellitus is a chronic, metabolic, noncommunicable disease that has attained epidemic proportions. At present, there is emerging evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Optical coherence tomography (OCT) is a noninvasive technique to detect the earliest retinal changes before DR could be diagnosed on fundus examination. Aims: The purpose of the study was to measure retinal ganglion cell inner-plexiform layer (GC-IPL) thickness in diabetic patients with no DR or with mild nonproliferative DR (NPDR) on fundus examination. Settings and Design: This cross-sectional study was undertaken at a tertiary care hospital in North India over a period of 18 months. Subjects and Methods: Thirty-six subjects with diabetes were analyzed to study the occurrence of retinal neurodegeneration by measuring GC-IPL thickness on spectral domain-OCT (SD-OCT) examination and for comparison, GC-IPL thickness value of normal healthy nondiabetic subjects was taken (normal value taken 82.78 ± 7.01 μm). Statistical Analysis Used: Categorical variables were presented in number and percentage (%) and continuous variables were presented as mean ± standard deviation, median, and interquartile range. The normality of data was checked by applying the Shapiro–Wilk test and Chi-square test to check the association between two categorical variables. Results: There was no significant association of gender with the thickness of GC-IPL. The mean age, mean duration of diabetes, and mean glycated hemoglobin (HbA1c) levels were found to be significantly lower in diabetics with normal thickness GC-IPL as compared to those having thinner GC-IPL thickness. The mean value of average GC-IPL thickness among normal and mild NPDR fundus examinations was 86.24 μm and 75.43 μm, respectively (P = 0.000). Conclusions: Early detection of DR by SD-OCT can be a therapeutic window for neuroprotective treatments to reduce the damage to the retina in DR. Age, duration of diabetes, and HbA1c levels have a negative association with GC-IPL thickness in diabetics.https://journals.lww.com/10.4103/DLJO.DLJO_183_23diabetic retinopathyganglion cell-inner plexiform layeroptical coherence tomography |
| spellingShingle | Nimisha Kaushal Neha C. Guliani Brahm P. Guliani Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy Delhi Journal of Ophthalmology diabetic retinopathy ganglion cell-inner plexiform layer optical coherence tomography |
| title | Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy |
| title_full | Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy |
| title_fullStr | Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy |
| title_full_unstemmed | Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy |
| title_short | Profile of Macular Ganglion Cell-inner Plexiform Layer Thickness in Diabetics With and Without Retinopathy |
| title_sort | profile of macular ganglion cell inner plexiform layer thickness in diabetics with and without retinopathy |
| topic | diabetic retinopathy ganglion cell-inner plexiform layer optical coherence tomography |
| url | https://journals.lww.com/10.4103/DLJO.DLJO_183_23 |
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