The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death
The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD. We recently identified a PCD mechanism in Escherichia coli that is tr...
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Shared Science Publishers OG
2016-03-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/the-bacterial-cell-cycle-checkpoint-protein-obg-and-its-role-in-programmed-cell-death/ |
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| author | Liselot Dewachter Natalie Verstraeten Maarten Fauvart Jan Michiels |
| author_facet | Liselot Dewachter Natalie Verstraeten Maarten Fauvart Jan Michiels |
| author_sort | Liselot Dewachter |
| collection | DOAJ |
| description | The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD. We recently identified a PCD mechanism in Escherichia coli that is triggered by a mutant isoform of the essential GTPase ObgE (Obg of E. coli). Importantly, the PCD pathway mediated by mutant Obg (Obg*) differs fundamentally from other previously described bacterial PCD pathways and thus constitutes a new mode of PCD. ObgE was previously proposed to act as a cell cycle checkpoint protein able to halt cell division. The implication of ObgE in the regulation of PCD further increases the similarity between this protein and eukaryotic cell cycle regulators that are capable of doing both. Moreover, since Obg is conserved in eukaryotes, the elucidation of this cell death mechanism might contribute to the understanding of PCD in higher organisms. Additionally, if Obg*-mediated PCD is conserved among different bacterial species, it will be a prime target for the development of innovative antibacterials that artificially induce this pathway. |
| format | Article |
| id | doaj-art-d65c88cc5fcd4df89aac4fa36861f765 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-d65c88cc5fcd4df89aac4fa36861f7652025-08-20T02:57:39ZengShared Science Publishers OGMicrobial Cell2311-26382016-03-013625525610.15698/mic2016.06.507The bacterial cell cycle checkpoint protein Obg and its role in programmed cell deathLiselot Dewachter0Natalie Verstraeten1Maarten Fauvart2Jan Michiels3Centre of Microbial and Plant Genetics, KU Leuven – University of Leuven, 3001 Leuven, Belgium.Centre of Microbial and Plant Genetics, KU Leuven – University of Leuven, 3001 Leuven, Belgium.Centre of Microbial and Plant Genetics, KU Leuven – University of Leuven, 3001 Leuven, Belgium.Centre of Microbial and Plant Genetics, KU Leuven – University of Leuven, 3001 Leuven, Belgium.The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD. We recently identified a PCD mechanism in Escherichia coli that is triggered by a mutant isoform of the essential GTPase ObgE (Obg of E. coli). Importantly, the PCD pathway mediated by mutant Obg (Obg*) differs fundamentally from other previously described bacterial PCD pathways and thus constitutes a new mode of PCD. ObgE was previously proposed to act as a cell cycle checkpoint protein able to halt cell division. The implication of ObgE in the regulation of PCD further increases the similarity between this protein and eukaryotic cell cycle regulators that are capable of doing both. Moreover, since Obg is conserved in eukaryotes, the elucidation of this cell death mechanism might contribute to the understanding of PCD in higher organisms. Additionally, if Obg*-mediated PCD is conserved among different bacterial species, it will be a prime target for the development of innovative antibacterials that artificially induce this pathway.http://microbialcell.com/researcharticles/the-bacterial-cell-cycle-checkpoint-protein-obg-and-its-role-in-programmed-cell-death/ObgObgE CgtA programmed cell deathapoptosis |
| spellingShingle | Liselot Dewachter Natalie Verstraeten Maarten Fauvart Jan Michiels The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death Microbial Cell Obg ObgE CgtA programmed cell death apoptosis |
| title | The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death |
| title_full | The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death |
| title_fullStr | The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death |
| title_full_unstemmed | The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death |
| title_short | The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death |
| title_sort | bacterial cell cycle checkpoint protein obg and its role in programmed cell death |
| topic | Obg ObgE CgtA programmed cell death apoptosis |
| url | http://microbialcell.com/researcharticles/the-bacterial-cell-cycle-checkpoint-protein-obg-and-its-role-in-programmed-cell-death/ |
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