Aging-associated interleukin-11 drives the molecular mechanism and targeted therapy of idiopathic pulmonary fibrosis

Aging-associated interleukin-11 drives the molecular mechanism and targeted therapy of idiopathic pulmonary fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is an unexplained interstitial lung disease in which senescence is a central risk factor. Senescent cells drive chronic inflammation and fibrosis by the secreting senescence-associated secretory phenotype (SASP). Interleukin-11 (IL-11), a core factor in t...

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Bibliographic Details
Main Authors: Jie Zhou, Xing An, Xiuwen Xia, Wei Xiao, Ding Dou, Weihong Li, Qingsong Huang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Idiopathic pulmonary fibrosis
Interleukin-11
Aging
Molecular mechanisms
Targeted therapy
Online Access:https://doi.org/10.1186/s40001-025-02755-5
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