Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China
Abstract Purpose Different health-related quality of life scales are suitable for various populations and scenarios; hence, the selection of measurement tools must be based on research objectives and focal points. To facilitate the choice between EQ-5D-5L and SF-6Dv1 in clinical and economic researc...
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| Language: | English |
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BMC
2025-08-01
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| Series: | Health and Quality of Life Outcomes |
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| Online Access: | https://doi.org/10.1186/s12955-025-02411-w |
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| author | Gang Liang Ai-Xue Zhang Fang-Yu Li Jian-Hua Liu Ya-Jie Zheng Yu Qin Yue-Zu Li Rong Ma Chen-Wei Pan Dan-Lin Li Pei Wang |
| author_facet | Gang Liang Ai-Xue Zhang Fang-Yu Li Jian-Hua Liu Ya-Jie Zheng Yu Qin Yue-Zu Li Rong Ma Chen-Wei Pan Dan-Lin Li Pei Wang |
| author_sort | Gang Liang |
| collection | DOAJ |
| description | Abstract Purpose Different health-related quality of life scales are suitable for various populations and scenarios; hence, the selection of measurement tools must be based on research objectives and focal points. To facilitate the choice between EQ-5D-5L and SF-6Dv1 in clinical and economic research of myopic patients undergoing corneal refractive surgery, the study aims to assess and compare EQ-5D-5L and SF-6Dv1 among the patients in China. Methods A total of 411 participants with a mean age of 25.6 years were recruited. Information collected including demographic characteristics, EQ-5D-5L and SF-6Dv1. The ceiling effect was evaluated by calculating the proportion of participants who reported the best possible health states. Agreement between EQ-5D-5L and SF-6Dv1 health utility scores (HUSs) was tested using intraclass correlation coefficient (ICC) and Bland-Altman plot. Convergent validity of EQ-5D-5L and SF-6Dv1 HUSs was evaluated using the Spearman correlation coefficient (r) with VF-14 as a calibration standard. Results Ceiling effects were 75.2% and 40.4% for EQ-5D-5L and SF-6Dv1, respectively. ICC between the two HUSs was 0.611 (average-measure). Bland-Altman plots showed that the agreement varied across different HUS segments. Correlation between EQ-5D-5L HUS and VF-14 (r = 0.363) was higher than that between SF-6Dv1 HUS and VF-14 (r = 0.226). EQ-5D-5L and SF-6Dv1 HUSs can only distinguish one clinical condition (i.e., chronic pain symptom); but they can identify health differences across all self-reported known-groups. EQ-5D-5L HUS had greater sensitivity; but SF-6Dv1 HUS was more responsive at follow-ups. Conclusions EQ-5D-5L and SF-6Dv1 HUS cannot be used interchangeably in myopic patients undergoing corneal refractive surgery. It appears that EQ-5D-5L HUS performs better in terms of convergent validity and sensitivity; but SF-6Dv1 HUS is more responsive. |
| format | Article |
| id | doaj-art-d6582556831c49b4b4e9ea061be02c6f |
| institution | Kabale University |
| issn | 1477-7525 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj-art-d6582556831c49b4b4e9ea061be02c6f2025-08-24T11:51:35ZengBMCHealth and Quality of Life Outcomes1477-75252025-08-0123111010.1186/s12955-025-02411-wValidation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in ChinaGang Liang0Ai-Xue Zhang1Fang-Yu Li2Jian-Hua Liu3Ya-Jie Zheng4Yu Qin5Yue-Zu Li6Rong Ma7Chen-Wei Pan8Dan-Lin Li9Pei Wang10Department of Ophthalmology, the Affiliated Hospital of Yunnan UniversityAerospace Center HospitalKey Lab of Health Technology Assessment, National Health Commission of the People’s Republic of China (Fudan University)School of Public Health, Suzhou Medical College of Soochow UniversityDepartment of Ophthalmology, the Affiliated Hospital of Yunnan UniversityDepartment of Ophthalmology, the Affiliated Hospital of Yunnan UniversityDepartment of Ophthalmology, the Affiliated Hospital of Yunnan UniversityDepartment of Ophthalmology, the Affiliated Hospital of Yunnan UniversitySchool of Public Health, Suzhou Medical College of Soochow UniversitySchool of Public Health, Suzhou Medical College of Soochow UniversityKey Lab of Health Technology Assessment, National Health Commission of the People’s Republic of China (Fudan University)Abstract Purpose Different health-related quality of life scales are suitable for various populations and scenarios; hence, the selection of measurement tools must be based on research objectives and focal points. To facilitate the choice between EQ-5D-5L and SF-6Dv1 in clinical and economic research of myopic patients undergoing corneal refractive surgery, the study aims to assess and compare EQ-5D-5L and SF-6Dv1 among the patients in China. Methods A total of 411 participants with a mean age of 25.6 years were recruited. Information collected including demographic characteristics, EQ-5D-5L and SF-6Dv1. The ceiling effect was evaluated by calculating the proportion of participants who reported the best possible health states. Agreement between EQ-5D-5L and SF-6Dv1 health utility scores (HUSs) was tested using intraclass correlation coefficient (ICC) and Bland-Altman plot. Convergent validity of EQ-5D-5L and SF-6Dv1 HUSs was evaluated using the Spearman correlation coefficient (r) with VF-14 as a calibration standard. Results Ceiling effects were 75.2% and 40.4% for EQ-5D-5L and SF-6Dv1, respectively. ICC between the two HUSs was 0.611 (average-measure). Bland-Altman plots showed that the agreement varied across different HUS segments. Correlation between EQ-5D-5L HUS and VF-14 (r = 0.363) was higher than that between SF-6Dv1 HUS and VF-14 (r = 0.226). EQ-5D-5L and SF-6Dv1 HUSs can only distinguish one clinical condition (i.e., chronic pain symptom); but they can identify health differences across all self-reported known-groups. EQ-5D-5L HUS had greater sensitivity; but SF-6Dv1 HUS was more responsive at follow-ups. Conclusions EQ-5D-5L and SF-6Dv1 HUS cannot be used interchangeably in myopic patients undergoing corneal refractive surgery. It appears that EQ-5D-5L HUS performs better in terms of convergent validity and sensitivity; but SF-6Dv1 HUS is more responsive.https://doi.org/10.1186/s12955-025-02411-wMyopiaCorneal refractive surgeryEQ-5D-5LSF-6Dv1Health utility |
| spellingShingle | Gang Liang Ai-Xue Zhang Fang-Yu Li Jian-Hua Liu Ya-Jie Zheng Yu Qin Yue-Zu Li Rong Ma Chen-Wei Pan Dan-Lin Li Pei Wang Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China Health and Quality of Life Outcomes Myopia Corneal refractive surgery EQ-5D-5L SF-6Dv1 Health utility |
| title | Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China |
| title_full | Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China |
| title_fullStr | Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China |
| title_full_unstemmed | Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China |
| title_short | Validation and comparison of EQ-5D-5L and SF-6Dv1 in myopic patients requiring corneal refractive surgery in China |
| title_sort | validation and comparison of eq 5d 5l and sf 6dv1 in myopic patients requiring corneal refractive surgery in china |
| topic | Myopia Corneal refractive surgery EQ-5D-5L SF-6Dv1 Health utility |
| url | https://doi.org/10.1186/s12955-025-02411-w |
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