Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation
Although the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The <i>Mycobacterium tuberculosis</i> complex (MTBC) including <i>M. tuberculosis</i>, <i>M. bovis</i>, <i>M. microti<...
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MDPI AG
2025-05-01
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| author | Xinting Zhang Yikai Zhang Xiao Feng Yueying Wang Si-Shang Li Mei-Yi Yan Yi-Cheng Sun Qi Jin Feng Jiang |
| author_facet | Xinting Zhang Yikai Zhang Xiao Feng Yueying Wang Si-Shang Li Mei-Yi Yan Yi-Cheng Sun Qi Jin Feng Jiang |
| author_sort | Xinting Zhang |
| collection | DOAJ |
| description | Although the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The <i>Mycobacterium tuberculosis</i> complex (MTBC) including <i>M. tuberculosis</i>, <i>M. bovis</i>, <i>M. microti</i>, etc., is the deadliest <i>Mycobacterium</i> spp. that needs more attention. Research on <i>M. microti</i> is significant as it is a zoonotic pathogen that can spread between animals and humans. By exploring the function of a transglutaminase in <i>M. microti</i> (MmTG), which is widely distributed in <i>Mycobacterium</i> and other species, a potential cytotoxic effector has been characterized. MmTG inhibits cell proliferation by inducing the phosphorylation of RIPK1 (receptor-interacting serine/threonine-protein kinase 1) and the Cys159 of MmTG is the highly conserved residue related to its cytotoxicity. Understanding MmTG and its homologs can provide more insights into the pathogenic mechanisms of mycobacteria and contribute to the development of more effective therapeutic strategies against mycobacterial infections. |
| format | Article |
| id | doaj-art-d656e2e6b688409db4f1d4ae08d931f3 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-d656e2e6b688409db4f1d4ae08d931f32025-08-20T03:48:02ZengMDPI AGMolecules1420-30492025-05-013010225110.3390/molecules30102251Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 ActivationXinting Zhang0Yikai Zhang1Xiao Feng2Yueying Wang3Si-Shang Li4Mei-Yi Yan5Yi-Cheng Sun6Qi Jin7Feng Jiang8NHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, ChinaAlthough the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The <i>Mycobacterium tuberculosis</i> complex (MTBC) including <i>M. tuberculosis</i>, <i>M. bovis</i>, <i>M. microti</i>, etc., is the deadliest <i>Mycobacterium</i> spp. that needs more attention. Research on <i>M. microti</i> is significant as it is a zoonotic pathogen that can spread between animals and humans. By exploring the function of a transglutaminase in <i>M. microti</i> (MmTG), which is widely distributed in <i>Mycobacterium</i> and other species, a potential cytotoxic effector has been characterized. MmTG inhibits cell proliferation by inducing the phosphorylation of RIPK1 (receptor-interacting serine/threonine-protein kinase 1) and the Cys159 of MmTG is the highly conserved residue related to its cytotoxicity. Understanding MmTG and its homologs can provide more insights into the pathogenic mechanisms of mycobacteria and contribute to the development of more effective therapeutic strategies against mycobacterial infections.https://www.mdpi.com/1420-3049/30/10/2251<i>Mycobacterium</i> spp.MmTGRIPK1cytotoxicitytransglutaminase |
| spellingShingle | Xinting Zhang Yikai Zhang Xiao Feng Yueying Wang Si-Shang Li Mei-Yi Yan Yi-Cheng Sun Qi Jin Feng Jiang Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation Molecules <i>Mycobacterium</i> spp. MmTG RIPK1 cytotoxicity transglutaminase |
| title | Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation |
| title_full | Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation |
| title_fullStr | Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation |
| title_full_unstemmed | Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation |
| title_short | Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation |
| title_sort | identification of the cytotoxic transglutaminase from i mycobacterium i spp that is involved in ripk1 activation |
| topic | <i>Mycobacterium</i> spp. MmTG RIPK1 cytotoxicity transglutaminase |
| url | https://www.mdpi.com/1420-3049/30/10/2251 |
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