Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expr...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1738676 |
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| author | Claudia Pinacchio Giuseppe Corano Scheri Maura Statzu Letizia Santinelli Giancarlo Ceccarelli Giuseppe Pietro Innocenti Vincenzo Vullo Guido Antonelli Jason M. Brenchley Gabriella d’Ettorre Carolina Scagnolari |
| author_facet | Claudia Pinacchio Giuseppe Corano Scheri Maura Statzu Letizia Santinelli Giancarlo Ceccarelli Giuseppe Pietro Innocenti Vincenzo Vullo Guido Antonelli Jason M. Brenchley Gabriella d’Ettorre Carolina Scagnolari |
| author_sort | Claudia Pinacchio |
| collection | DOAJ |
| description | Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation. |
| format | Article |
| id | doaj-art-d6551d931b6d439fa4c62396d1f85527 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d6551d931b6d439fa4c62396d1f855272025-08-20T02:19:40ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/17386761738676Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic SupplementationClaudia Pinacchio0Giuseppe Corano Scheri1Maura Statzu2Letizia Santinelli3Giancarlo Ceccarelli4Giuseppe Pietro Innocenti5Vincenzo Vullo6Guido Antonelli7Jason M. Brenchley8Gabriella d’Ettorre9Carolina Scagnolari10Department of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, ItalyDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, ItalyLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USADepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, ItalyExpression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.http://dx.doi.org/10.1155/2018/1738676 |
| spellingShingle | Claudia Pinacchio Giuseppe Corano Scheri Maura Statzu Letizia Santinelli Giancarlo Ceccarelli Giuseppe Pietro Innocenti Vincenzo Vullo Guido Antonelli Jason M. Brenchley Gabriella d’Ettorre Carolina Scagnolari Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation Journal of Immunology Research |
| title | Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation |
| title_full | Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation |
| title_fullStr | Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation |
| title_full_unstemmed | Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation |
| title_short | Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation |
| title_sort | type i ii interferon in hiv 1 infected patients expression in gut mucosa and in peripheral blood mononuclear cells and its modification upon probiotic supplementation |
| url | http://dx.doi.org/10.1155/2018/1738676 |
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