Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex

Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex

Abnormalities in the mammalian target of the rapamycin (mTOR) pathway have been implicated in numerous developmental brain disorders. While the molecular and histological abnormalities have been described, less is known about alterations in membrane and synaptic excitability with chronic changes in...

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Bibliographic Details
Main Authors: Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
mTOR
rapamycin
electrophysiology
cerebral cortex
Online Access:https://www.mdpi.com/2073-4409/14/2/79
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