Pathology and gene mutations of aldosterone-producing lesions
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and...
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The Japan Endocrine Society
2023-12-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ22-0492/_html/-char/en |
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| author | Koshiro Nishimoto Tadashi Ogishima Yuki Sugiura Makoto Suematsu Kuniaki Mukai |
| author_facet | Koshiro Nishimoto Tadashi Ogishima Yuki Sugiura Makoto Suematsu Kuniaki Mukai |
| author_sort | Koshiro Nishimoto |
| collection | DOAJ |
| description | The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for CYP11B2 of both rats and humans and applied it clinically to visualize the functional histology of aldosterone-producing adenoma (APA) causing primary aldosteronism (PA). We discovered aldosterone-producing cell clusters (APCCs) and possible APCC-to-APA transitional lesions (pAATLs) and further visualized aldosterone-producing lesions for rare forms of PA including familial hyperaldosteronism type 3 and novel non-familial juvenile PA. Here we review the history of our research on aldosterone-producing lesions. |
| format | Article |
| id | doaj-art-d64fbc05fb574bae955f0ef52c358448 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-d64fbc05fb574bae955f0ef52c3584482025-01-22T06:25:09ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-12-0170121113112210.1507/endocrj.EJ22-0492endocrjPathology and gene mutations of aldosterone-producing lesionsKoshiro Nishimoto0Tadashi Ogishima1Yuki Sugiura2Makoto Suematsu3Kuniaki Mukai4Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, JapanDepartment of Chemistry, Graduate School of Science, Kyushu University, Fukuoka 819-0395, JapanDepartment of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, JapanKeio University WPI Bio2Q Research Center and Central Institute for Experimental Animal, Kanagawa 210-0821, JapanDepartment of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, JapanThe human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for CYP11B2 of both rats and humans and applied it clinically to visualize the functional histology of aldosterone-producing adenoma (APA) causing primary aldosteronism (PA). We discovered aldosterone-producing cell clusters (APCCs) and possible APCC-to-APA transitional lesions (pAATLs) and further visualized aldosterone-producing lesions for rare forms of PA including familial hyperaldosteronism type 3 and novel non-familial juvenile PA. Here we review the history of our research on aldosterone-producing lesions.https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ22-0492/_html/-char/enaldosteronealdosterone synthasecyp11b2immunohistochemistryaldosterone-producing cell clusters (apcc) |
| spellingShingle | Koshiro Nishimoto Tadashi Ogishima Yuki Sugiura Makoto Suematsu Kuniaki Mukai Pathology and gene mutations of aldosterone-producing lesions Endocrine Journal aldosterone aldosterone synthase cyp11b2 immunohistochemistry aldosterone-producing cell clusters (apcc) |
| title | Pathology and gene mutations of aldosterone-producing lesions |
| title_full | Pathology and gene mutations of aldosterone-producing lesions |
| title_fullStr | Pathology and gene mutations of aldosterone-producing lesions |
| title_full_unstemmed | Pathology and gene mutations of aldosterone-producing lesions |
| title_short | Pathology and gene mutations of aldosterone-producing lesions |
| title_sort | pathology and gene mutations of aldosterone producing lesions |
| topic | aldosterone aldosterone synthase cyp11b2 immunohistochemistry aldosterone-producing cell clusters (apcc) |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ22-0492/_html/-char/en |
| work_keys_str_mv | AT koshironishimoto pathologyandgenemutationsofaldosteroneproducinglesions AT tadashiogishima pathologyandgenemutationsofaldosteroneproducinglesions AT yukisugiura pathologyandgenemutationsofaldosteroneproducinglesions AT makotosuematsu pathologyandgenemutationsofaldosteroneproducinglesions AT kuniakimukai pathologyandgenemutationsofaldosteroneproducinglesions |