Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment
Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which is a serious threat to human life and health. Inflammatory and immune responses are initiated immediately after MI, and unbalanced inflammation post-MI can lead to cardiac dysfunction, sca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/2/205 |
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| author | Wenyuan Zhang Dan Peng Shiqi Cheng Rui Ni Meiyang Yang Yongqing Cai Jianhong Chen Fang Liu Yao Liu |
| author_facet | Wenyuan Zhang Dan Peng Shiqi Cheng Rui Ni Meiyang Yang Yongqing Cai Jianhong Chen Fang Liu Yao Liu |
| author_sort | Wenyuan Zhang |
| collection | DOAJ |
| description | Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which is a serious threat to human life and health. Inflammatory and immune responses are initiated immediately after MI, and unbalanced inflammation post-MI can lead to cardiac dysfunction, scarring, and ventricular remodeling, emphasizing the critical need for an effective inflammation-regulating treatment. With the development of novel therapies, the drug delivery system specific to inflammatory cells offers significant potential. In this review, we introduce immune cells and fibroblasts involved in the development of MI and summarize the newly developed delivery systems related to the use of injectable hydrogels, cardiac patches, nanoparticles, and extracellular vesicles (EVs). Finally, we highlight the recent trends in the use of inflammatory cell-targeting drug delivery systems involving different strategies that facilitate the effective treatment of MI. |
| format | Article |
| id | doaj-art-d6480a7545e14aabab8f8929cbce0bd2 |
| institution | DOAJ |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-d6480a7545e14aabab8f8929cbce0bd22025-08-20T02:44:36ZengMDPI AGBioengineering2306-53542025-02-0112220510.3390/bioengineering12020205Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction TreatmentWenyuan Zhang0Dan Peng1Shiqi Cheng2Rui Ni3Meiyang Yang4Yongqing Cai5Jianhong Chen6Fang Liu7Yao Liu8Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing 400042, ChinaMyocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which is a serious threat to human life and health. Inflammatory and immune responses are initiated immediately after MI, and unbalanced inflammation post-MI can lead to cardiac dysfunction, scarring, and ventricular remodeling, emphasizing the critical need for an effective inflammation-regulating treatment. With the development of novel therapies, the drug delivery system specific to inflammatory cells offers significant potential. In this review, we introduce immune cells and fibroblasts involved in the development of MI and summarize the newly developed delivery systems related to the use of injectable hydrogels, cardiac patches, nanoparticles, and extracellular vesicles (EVs). Finally, we highlight the recent trends in the use of inflammatory cell-targeting drug delivery systems involving different strategies that facilitate the effective treatment of MI.https://www.mdpi.com/2306-5354/12/2/205inflammationimmune cellsfibroblastsdelivery systemmyocardial infarction |
| spellingShingle | Wenyuan Zhang Dan Peng Shiqi Cheng Rui Ni Meiyang Yang Yongqing Cai Jianhong Chen Fang Liu Yao Liu Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment Bioengineering inflammation immune cells fibroblasts delivery system myocardial infarction |
| title | Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment |
| title_full | Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment |
| title_fullStr | Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment |
| title_full_unstemmed | Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment |
| title_short | Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment |
| title_sort | inflammatory cell targeted delivery systems for myocardial infarction treatment |
| topic | inflammation immune cells fibroblasts delivery system myocardial infarction |
| url | https://www.mdpi.com/2306-5354/12/2/205 |
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