Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals
Purpose. Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondia...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2019/8748459 |
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| author | Di-Shuang Hu Sheng-Hao Zhu Xu Li Qin-Fen Chen Chun-Jing Lin Dan-Hong Fang Jian-Sheng Wu |
| author_facet | Di-Shuang Hu Sheng-Hao Zhu Xu Li Qin-Fen Chen Chun-Jing Lin Dan-Hong Fang Jian-Sheng Wu |
| author_sort | Di-Shuang Hu |
| collection | DOAJ |
| description | Purpose. Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondiabetic individuals and to construct a risk score based on HGI to predict a person’s risk of NAFLD. Methods. After strict exclusion criteria, 5,903 individuals were included in this retrospective cross-sectional study. We randomly selected 1,967 subjects in the enrollment to obtain an equation of linear regression, which was used to calculate predicted HbA1c and drive HGI. The other subjects were classified into four categories according to HGI level (≤−0.22, −0.21∼0.02, 0.03∼0.28, and ≥0.29). All subjects retrospectively reviewed the baseline characteristics, laboratory examinations, and abdominal ultrasonography. Results. The prevalence of NAFLD in this population was 20.7%, which increases along with the growth of HGI levels (P<0.001). Adjusted to multiple factors, this trend still remained significant (OR: 1.172 (95% CI, 1.074–1.279)). The combined NAFLD risk score based on HGI resulted in an area under the receiver operator characteristic curve (AUROC) of 0.85 provided sensitivity, specificity, positive predictive value, and a negative predictive value for NAFLD of 84.4%, 71.3%, 65.0%, and 88.0%, respectively. Conclusions. NAFLD is independently associated with HGI levels in Chinese nondiabetic individuals. And, NAFLD risk score may be used as one of the risk predictors of NAFLD in nondiabetic population. |
| format | Article |
| id | doaj-art-d643d2d7646b4dcca1c30792dbe6af0a |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-d643d2d7646b4dcca1c30792dbe6af0a2025-08-20T02:19:40ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/87484598748459Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic IndividualsDi-Shuang Hu0Sheng-Hao Zhu1Xu Li2Qin-Fen Chen3Chun-Jing Lin4Dan-Hong Fang5Jian-Sheng Wu6Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaWenzhou Medical University RenJi College, Wenzhou 325000, Zhejiang, ChinaMedical and Health Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaMedical and Health Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaMedical and Health Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaMedical and Health Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaPurpose. Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondiabetic individuals and to construct a risk score based on HGI to predict a person’s risk of NAFLD. Methods. After strict exclusion criteria, 5,903 individuals were included in this retrospective cross-sectional study. We randomly selected 1,967 subjects in the enrollment to obtain an equation of linear regression, which was used to calculate predicted HbA1c and drive HGI. The other subjects were classified into four categories according to HGI level (≤−0.22, −0.21∼0.02, 0.03∼0.28, and ≥0.29). All subjects retrospectively reviewed the baseline characteristics, laboratory examinations, and abdominal ultrasonography. Results. The prevalence of NAFLD in this population was 20.7%, which increases along with the growth of HGI levels (P<0.001). Adjusted to multiple factors, this trend still remained significant (OR: 1.172 (95% CI, 1.074–1.279)). The combined NAFLD risk score based on HGI resulted in an area under the receiver operator characteristic curve (AUROC) of 0.85 provided sensitivity, specificity, positive predictive value, and a negative predictive value for NAFLD of 84.4%, 71.3%, 65.0%, and 88.0%, respectively. Conclusions. NAFLD is independently associated with HGI levels in Chinese nondiabetic individuals. And, NAFLD risk score may be used as one of the risk predictors of NAFLD in nondiabetic population.http://dx.doi.org/10.1155/2019/8748459 |
| spellingShingle | Di-Shuang Hu Sheng-Hao Zhu Xu Li Qin-Fen Chen Chun-Jing Lin Dan-Hong Fang Jian-Sheng Wu Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals Canadian Journal of Gastroenterology and Hepatology |
| title | Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals |
| title_full | Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals |
| title_fullStr | Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals |
| title_full_unstemmed | Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals |
| title_short | Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals |
| title_sort | association between hemoglobin glycation index and nafld in chinese nondiabetic individuals |
| url | http://dx.doi.org/10.1155/2019/8748459 |
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