Beyond the icebox: modern strategies in organ preservation for transplantation
Organ transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. This review explores the progress of organ preservation, focusing on the...
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| Format: | Article |
| Language: | English |
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The Korean Society for Transplantation
2024-12-01
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| Series: | Clinical Transplantation and Research |
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| Online Access: | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0039 |
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| author | Kidus Haile Yemaneberhan Minseok Kang Jun Hwan Jang Jin Hee Kim Kyeong Sik Kim Ho Bum Park Dongho Choi |
| author_facet | Kidus Haile Yemaneberhan Minseok Kang Jun Hwan Jang Jin Hee Kim Kyeong Sik Kim Ho Bum Park Dongho Choi |
| author_sort | Kidus Haile Yemaneberhan |
| collection | DOAJ |
| description | Organ transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. This review explores the progress of organ preservation, focusing on the shift from static cold storage (SCS) to advanced machine perfusion techniques such as hypothermic (HMP) and normothermic machine perfusion (NMP). Although SCS has been the standard approach, its limitations in preserving marginal organs and preventing ischemia-reperfusion injury (IRI) have led to the adoption of HMP and NMP. HMP, which is now the gold standard for high-risk donor kidneys, reduces metabolic activity and improves posttransplant outcomes. NMP allows real-time organ viability assessment and reconditioning, especially for liver transplants. Controlled oxygenated rewarming further minimizes IRI by addressing mitochondrial dysfunction. The review also highlights the potential of cryopreservation for long-term organ storage, despite challenges with ice formation. These advances are crucial for expanding the donor pool, improving transplant success rates, and addressing organ shortages. Continued innovation is necessary to meet the growing demands of transplantation and save more lives. |
| format | Article |
| id | doaj-art-d6424fe4fba142f58c6cd532e0e15176 |
| institution | Kabale University |
| issn | 3022-6783 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Korean Society for Transplantation |
| record_format | Article |
| series | Clinical Transplantation and Research |
| spelling | doaj-art-d6424fe4fba142f58c6cd532e0e151762025-01-15T02:52:00ZengThe Korean Society for TransplantationClinical Transplantation and Research3022-67832024-12-0138437740310.4285/ctr.24.0039ctr.24.0039Beyond the icebox: modern strategies in organ preservation for transplantationKidus Haile Yemaneberhan0Minseok Kang1Jun Hwan Jang2Jin Hee Kim3Kyeong Sik Kim4Ho Bum Park5Dongho Choi6Department of Surgery, Hanyang University College of Medicine, Seoul, KoreaDepartment of Surgery, Hanyang University College of Medicine, Seoul, KoreaDepartment of Energy Engineering, Hanyang University, Seoul, KoreaDepartment of Energy Engineering, Hanyang University, Seoul, KoreaDepartment of Surgery, Hanyang University College of Medicine, Seoul, KoreaDepartment of Energy Engineering, Hanyang University, Seoul, KoreaDepartment of Surgery, Hanyang University College of Medicine, Seoul, KoreaOrgan transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. This review explores the progress of organ preservation, focusing on the shift from static cold storage (SCS) to advanced machine perfusion techniques such as hypothermic (HMP) and normothermic machine perfusion (NMP). Although SCS has been the standard approach, its limitations in preserving marginal organs and preventing ischemia-reperfusion injury (IRI) have led to the adoption of HMP and NMP. HMP, which is now the gold standard for high-risk donor kidneys, reduces metabolic activity and improves posttransplant outcomes. NMP allows real-time organ viability assessment and reconditioning, especially for liver transplants. Controlled oxygenated rewarming further minimizes IRI by addressing mitochondrial dysfunction. The review also highlights the potential of cryopreservation for long-term organ storage, despite challenges with ice formation. These advances are crucial for expanding the donor pool, improving transplant success rates, and addressing organ shortages. Continued innovation is necessary to meet the growing demands of transplantation and save more lives.https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0039organ transplantation; machine perfusion; cryopreservation; nanobiotechnology |
| spellingShingle | Kidus Haile Yemaneberhan Minseok Kang Jun Hwan Jang Jin Hee Kim Kyeong Sik Kim Ho Bum Park Dongho Choi Beyond the icebox: modern strategies in organ preservation for transplantation Clinical Transplantation and Research organ transplantation; machine perfusion; cryopreservation; nanobiotechnology |
| title | Beyond the icebox: modern strategies in organ preservation for transplantation |
| title_full | Beyond the icebox: modern strategies in organ preservation for transplantation |
| title_fullStr | Beyond the icebox: modern strategies in organ preservation for transplantation |
| title_full_unstemmed | Beyond the icebox: modern strategies in organ preservation for transplantation |
| title_short | Beyond the icebox: modern strategies in organ preservation for transplantation |
| title_sort | beyond the icebox modern strategies in organ preservation for transplantation |
| topic | organ transplantation; machine perfusion; cryopreservation; nanobiotechnology |
| url | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0039 |
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