A synergistic effect of herb and acupuncture on the methamphetamine
Background: Herbal medicine Ja-Geum-Jeong (JGJ) has been used for the treatment of detoxification in Eastern Asia. However, the mechanisms involved are not clearly defined. The purpose of the present study was to investigate if herb medication inhibits Methamphetamine (METH)’s reinforcing effect and...
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Elsevier
2024-09-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000325 |
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| author | Jin Gyeom Lee Yuchi Li Nam Jun Kim Han Byeol Jang Chae Ha Yang Hee Young Kim Seong Shoon Yoon Suchan Chang Seon-Ju Jeong Sang Chan Kim Bok Suk Sa Bong Hyo Lee |
| author_facet | Jin Gyeom Lee Yuchi Li Nam Jun Kim Han Byeol Jang Chae Ha Yang Hee Young Kim Seong Shoon Yoon Suchan Chang Seon-Ju Jeong Sang Chan Kim Bok Suk Sa Bong Hyo Lee |
| author_sort | Jin Gyeom Lee |
| collection | DOAJ |
| description | Background: Herbal medicine Ja-Geum-Jeong (JGJ) has been used for the treatment of detoxification in Eastern Asia. However, the mechanisms involved are not clearly defined. The purpose of the present study was to investigate if herb medication inhibits Methamphetamine (METH)’s reinforcing effect and also examined if a combination of herb medication and acupuncture produces a synergistic effect on METH. Methods: Male Sprague-Dawley rats were given acute METH intraperitoneally and the locomotor activity and ultrasonic vocalization (USV) calls were measured. Rats were administered JGJ orally and acupuncture was given at HT7 or SI5. Monosodium glutamate (MSG) and gamma-aminobutyric acid (GABA) agonists were injected into the Central amygdala (CeA) to investigate a possible neuroscientific mechanism. Tyrosine hydroxylase (TH) and fast scan cyclic voltammetry (FSCV) were measured to immunohistochemically and electrically confirm the behavioral data. Results: Locomotor activity and USV calls were increased by METH (P < 0.05) and these increases were inhibited by JGJ (P < 0.05). Also, JGJ had no effect on the normal group given saline, and acupuncture at SI5 acupoint, but not at HT7 acupoint, produced a synergistic effect when combined with JGJ (P < 0.05). The JGJ's inhibition was blocked by the inactivation of CeA (P < 0.05), and MSG mimicked JGJ (P < 0.05). TH and FSCV measures showed the same pattern with the behavioral data (P < 0.05). Conclusion: Results of the present study suggest that JGJ had inhibitory effects on the METH which was mediated through the activation of CeA and that combination of acupuncture and herb produced synergistic effect. |
| format | Article |
| id | doaj-art-d641fc56071d47ee8b355fb4cdfd4645 |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-d641fc56071d47ee8b355fb4cdfd46452025-08-20T03:24:40ZengElsevierIntegrative Medicine Research2213-42202024-09-0113310105210.1016/j.imr.2024.101052A synergistic effect of herb and acupuncture on the methamphetamineJin Gyeom Lee0Yuchi Li1Nam Jun Kim2Han Byeol Jang3Chae Ha Yang4Hee Young Kim5Seong Shoon Yoon6Suchan Chang7Seon-Ju Jeong8Sang Chan Kim9Bok Suk Sa10Bong Hyo Lee11Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, Republic of Korea; Research Center for Herbal Convergence on Liver Disease, Daegu Haany University, Gyeongsan, Republic of KoreaChina Novartis Institutes for BioMedical Research, PR ChinaDepartment of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, Republic of Korea; Research Center for Herbal Convergence on Liver Disease, Daegu Haany University, Gyeongsan, Republic of KoreaDepartment of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, Republic of Korea; Research Center for Herbal Convergence on Liver Disease, Daegu Haany University, Gyeongsan, Republic of KoreaDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, Republic of KoreaDepartment of Physiology, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, Republic of KoreaDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, Republic of KoreaDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, Republic of KoreaResearch Center for Herbal Convergence on Liver Disease, Daegu Haany University, Gyeongsan, Republic of Korea; Department of Herbal Formula, College of Biomedical Science, Daegu Haany University, Daegu, Republic of KoreaChung Shin Herbal Medicine, Daegu, Republic of KoreaDepartment of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, Republic of Korea; Research Center for Herbal Convergence on Liver Disease, Daegu Haany University, Gyeongsan, Republic of Korea; Corresponding author at: Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, 136 Shincheondong-ro, Suseong-Gu, Daegu 42158, Republic of Korea.Background: Herbal medicine Ja-Geum-Jeong (JGJ) has been used for the treatment of detoxification in Eastern Asia. However, the mechanisms involved are not clearly defined. The purpose of the present study was to investigate if herb medication inhibits Methamphetamine (METH)’s reinforcing effect and also examined if a combination of herb medication and acupuncture produces a synergistic effect on METH. Methods: Male Sprague-Dawley rats were given acute METH intraperitoneally and the locomotor activity and ultrasonic vocalization (USV) calls were measured. Rats were administered JGJ orally and acupuncture was given at HT7 or SI5. Monosodium glutamate (MSG) and gamma-aminobutyric acid (GABA) agonists were injected into the Central amygdala (CeA) to investigate a possible neuroscientific mechanism. Tyrosine hydroxylase (TH) and fast scan cyclic voltammetry (FSCV) were measured to immunohistochemically and electrically confirm the behavioral data. Results: Locomotor activity and USV calls were increased by METH (P < 0.05) and these increases were inhibited by JGJ (P < 0.05). Also, JGJ had no effect on the normal group given saline, and acupuncture at SI5 acupoint, but not at HT7 acupoint, produced a synergistic effect when combined with JGJ (P < 0.05). The JGJ's inhibition was blocked by the inactivation of CeA (P < 0.05), and MSG mimicked JGJ (P < 0.05). TH and FSCV measures showed the same pattern with the behavioral data (P < 0.05). Conclusion: Results of the present study suggest that JGJ had inhibitory effects on the METH which was mediated through the activation of CeA and that combination of acupuncture and herb produced synergistic effect.http://www.sciencedirect.com/science/article/pii/S2213422024000325Acupuncture-herb synergyMethamphetaminePsychostimulant |
| spellingShingle | Jin Gyeom Lee Yuchi Li Nam Jun Kim Han Byeol Jang Chae Ha Yang Hee Young Kim Seong Shoon Yoon Suchan Chang Seon-Ju Jeong Sang Chan Kim Bok Suk Sa Bong Hyo Lee A synergistic effect of herb and acupuncture on the methamphetamine Integrative Medicine Research Acupuncture-herb synergy Methamphetamine Psychostimulant |
| title | A synergistic effect of herb and acupuncture on the methamphetamine |
| title_full | A synergistic effect of herb and acupuncture on the methamphetamine |
| title_fullStr | A synergistic effect of herb and acupuncture on the methamphetamine |
| title_full_unstemmed | A synergistic effect of herb and acupuncture on the methamphetamine |
| title_short | A synergistic effect of herb and acupuncture on the methamphetamine |
| title_sort | synergistic effect of herb and acupuncture on the methamphetamine |
| topic | Acupuncture-herb synergy Methamphetamine Psychostimulant |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000325 |
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