Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts
Objective: Despite that, the odontoblasts of the dental pulp are considered a terminally differentiated type of cell. We were interested in investigating if they express any embryonic, mesenchymal, or neural stem cell markers, along with other differentiation markers they were reported to express pr...
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| Language: | English |
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Springer
2024-06-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905224000993 |
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| author | Heba Alzer Firas Alsoleihat |
| author_facet | Heba Alzer Firas Alsoleihat |
| author_sort | Heba Alzer |
| collection | DOAJ |
| description | Objective: Despite that, the odontoblasts of the dental pulp are considered a terminally differentiated type of cell. We were interested in investigating if they express any embryonic, mesenchymal, or neural stem cell markers, along with other differentiation markers they were reported to express previously. Methods: An immunohistochemistry study was performed on wisdom teeth extracted from healthy donors aged between 17 and 19 for dental reasons. Nine markers were tested: c-Myc, SOX2, MCAM, CD73, NCAM1, STRO1, osteocalcin, S100, and Thy1. Results: Odontoblasts expressed the following markers: embryonic stem cell markers SOX2, c-Myc, mesenchymal stem cell marker MCAM, the neural differentiation marker S100, and the osteogenic differentiation marker osteocalcin. Odontoblasts did not express the following markers: mesenchymal stem cell markers CD73, STRO1, Thy1, and neural stem cell marker NCAM1. Conclusion: These findings suggest that odontoblasts’ expression of these stem cell markers may enable them to dedifferentiate under certain conditions. Further investigation is needed into whether dental materials could induce such dedifferentiation for functional dentin regeneration. |
| format | Article |
| id | doaj-art-d63d0ccf9b3b42aa8371ec163a2fc399 |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-d63d0ccf9b3b42aa8371ec163a2fc3992025-08-20T02:56:24ZengSpringerSaudi Dental Journal1013-90522024-06-0136689489810.1016/j.sdentj.2024.03.011Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblastsHeba Alzer0Firas Alsoleihat1Department of Restorative Dentistry, School of Dentistry, University of Jordan, Amman 11942, Jordan; Corresponding author at: Department of Restorative Dentistry, School of Dentistry, The University of Jordan, Amman 11942 Jordan.Department of Restorative Dentistry, School of Dentistry, University of Jordan, Amman 11942, Jordan; Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, JordanObjective: Despite that, the odontoblasts of the dental pulp are considered a terminally differentiated type of cell. We were interested in investigating if they express any embryonic, mesenchymal, or neural stem cell markers, along with other differentiation markers they were reported to express previously. Methods: An immunohistochemistry study was performed on wisdom teeth extracted from healthy donors aged between 17 and 19 for dental reasons. Nine markers were tested: c-Myc, SOX2, MCAM, CD73, NCAM1, STRO1, osteocalcin, S100, and Thy1. Results: Odontoblasts expressed the following markers: embryonic stem cell markers SOX2, c-Myc, mesenchymal stem cell marker MCAM, the neural differentiation marker S100, and the osteogenic differentiation marker osteocalcin. Odontoblasts did not express the following markers: mesenchymal stem cell markers CD73, STRO1, Thy1, and neural stem cell marker NCAM1. Conclusion: These findings suggest that odontoblasts’ expression of these stem cell markers may enable them to dedifferentiate under certain conditions. Further investigation is needed into whether dental materials could induce such dedifferentiation for functional dentin regeneration.http://www.sciencedirect.com/science/article/pii/S1013905224000993OdontoblastsHuman dental pulp stem cellsEmbryonic stem cells markerNeural stem cells markerMesenchymal stem cells markerNeural crest |
| spellingShingle | Heba Alzer Firas Alsoleihat Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts Saudi Dental Journal Odontoblasts Human dental pulp stem cells Embryonic stem cells marker Neural stem cells marker Mesenchymal stem cells marker Neural crest |
| title | Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts |
| title_full | Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts |
| title_fullStr | Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts |
| title_full_unstemmed | Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts |
| title_short | Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts |
| title_sort | odontoblasts or odontocytes expression of stem cells markers and differentiation markers among human adult odontoblasts |
| topic | Odontoblasts Human dental pulp stem cells Embryonic stem cells marker Neural stem cells marker Mesenchymal stem cells marker Neural crest |
| url | http://www.sciencedirect.com/science/article/pii/S1013905224000993 |
| work_keys_str_mv | AT hebaalzer odontoblastsorodontocytesexpressionofstemcellsmarkersanddifferentiationmarkersamonghumanadultodontoblasts AT firasalsoleihat odontoblastsorodontocytesexpressionofstemcellsmarkersanddifferentiationmarkersamonghumanadultodontoblasts |