Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster
In ancient China, Ganoderma lucidum was believed to be a medical fungus that could increase lifespan. Recently, pharmacologic studies have found that polysaccharide peptides and triterpenoids extracted from Ganoderma lucidum have various physiological effects as active compounds. However, the effect...
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| Format: | Article |
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Tsinghua University Press
2021-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453020301543 |
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| author | Yi Zhang Hongfei Cai Zhu Tao Cheng Yuan Zhaojian Jiang Juyan Liu Hiroshi Kurihara Wendong Xu |
| author_facet | Yi Zhang Hongfei Cai Zhu Tao Cheng Yuan Zhaojian Jiang Juyan Liu Hiroshi Kurihara Wendong Xu |
| author_sort | Yi Zhang |
| collection | DOAJ |
| description | In ancient China, Ganoderma lucidum was believed to be a medical fungus that could increase lifespan. Recently, pharmacologic studies have found that polysaccharide peptides and triterpenoids extracted from Ganoderma lucidum have various physiological effects as active compounds. However, the effects of spore oil isolated from Ganoderma lucidum remains unknown. In this study, the biological effects of Ganoderma lucidum spore oil (GLSO) were evaluated using a Drosophila melanogaster model. Compared with untreated groups, groups treated with GLSO had significantly longer average and maximum lifespan in both normal conditions and under oxidative stress. The activities of various antioxidant enzymes were measured to determine the antioxidant effect of GLSO. GLSO treatment markedly enhanced total superoxide dismutase (SOD) and catalase (CAT) activity and decreased levels of malondialdehyde (MDA). Further, we found dose-dependent increases in the mRNA expression of Cu, Zn-SOD, Mn-SOD, and CAT in GLSO-treated groups. These results suggest that GLSO may effectively eliminate free radicals and extend lifespan in Drosophila. Future work should investigate the value of GLSO as a functional food for the prevention of aging in larger animal models. |
| format | Article |
| id | doaj-art-d6351437e5d64b1bb35e1cf44532116e |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-d6351437e5d64b1bb35e1cf44532116e2025-02-03T06:48:27ZengTsinghua University PressFood Science and Human Wellness2213-45302021-01-011013844Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogasterYi Zhang0Hongfei Cai1Zhu Tao2Cheng Yuan3Zhaojian Jiang4Juyan Liu5Hiroshi Kurihara6Wendong Xu7Institute of Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China; Postdoctoral Research Station of Guangzhou Pharmaceutical Holdings Limited, Guangdong 510130, ChinaChina; Institute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, ChinaInstitute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, ChinaInstitute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, ChinaInstitute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, ChinaInstitute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, ChinaPostdoctoral Research Station of Guangzhou Pharmaceutical Holdings Limited, Guangdong 510130, ChinaChina; Institute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, China; Guangzhou Pharmaceutical Holdings Ltd, Guangdong 510130, China; Corresponding author at: Guangzhou Pharmaceutical Holdings Ltd, Guangdong 510130, China.Institute of Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China; Institute of Traditional Chinese Medicine and Natural Products, Jinan University, 601, Huangpu Avenue West, Guangzhou, 510632, China; Corresponding author at: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, 601, Huangpu Avenue West, Guangzhou, 510632, ChinaPostdoctoral Research Station of Guangzhou Pharmaceutical Holdings Limited, Guangdong 510130, ChinaChina; Institute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, China; Corresponding author at: Institute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, China.In ancient China, Ganoderma lucidum was believed to be a medical fungus that could increase lifespan. Recently, pharmacologic studies have found that polysaccharide peptides and triterpenoids extracted from Ganoderma lucidum have various physiological effects as active compounds. However, the effects of spore oil isolated from Ganoderma lucidum remains unknown. In this study, the biological effects of Ganoderma lucidum spore oil (GLSO) were evaluated using a Drosophila melanogaster model. Compared with untreated groups, groups treated with GLSO had significantly longer average and maximum lifespan in both normal conditions and under oxidative stress. The activities of various antioxidant enzymes were measured to determine the antioxidant effect of GLSO. GLSO treatment markedly enhanced total superoxide dismutase (SOD) and catalase (CAT) activity and decreased levels of malondialdehyde (MDA). Further, we found dose-dependent increases in the mRNA expression of Cu, Zn-SOD, Mn-SOD, and CAT in GLSO-treated groups. These results suggest that GLSO may effectively eliminate free radicals and extend lifespan in Drosophila. Future work should investigate the value of GLSO as a functional food for the prevention of aging in larger animal models.http://www.sciencedirect.com/science/article/pii/S2213453020301543Ganoderma lucidum spore oilAntioxidant activityDrosophila melanogasterAnti-aging |
| spellingShingle | Yi Zhang Hongfei Cai Zhu Tao Cheng Yuan Zhaojian Jiang Juyan Liu Hiroshi Kurihara Wendong Xu Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster Food Science and Human Wellness Ganoderma lucidum spore oil Antioxidant activity Drosophila melanogaster Anti-aging |
| title | Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster |
| title_full | Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster |
| title_fullStr | Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster |
| title_full_unstemmed | Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster |
| title_short | Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster |
| title_sort | ganoderma lucidum spore oil glso a novel antioxidant extends the average life span in drosophila melanogaster |
| topic | Ganoderma lucidum spore oil Antioxidant activity Drosophila melanogaster Anti-aging |
| url | http://www.sciencedirect.com/science/article/pii/S2213453020301543 |
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