Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis
Introduction: Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress. It is characterized by chronic lymphocytic infiltration of the thyroid gland, leading to hy...
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| Format: | Article |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57938 |
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| author | Agnieszka Starzyk Piotr Charzewski |
| author_facet | Agnieszka Starzyk Piotr Charzewski |
| author_sort | Agnieszka Starzyk |
| collection | DOAJ |
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Introduction:
Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress. It is characterized by chronic lymphocytic infiltration of the thyroid gland, leading to hypothyroidism and the production of thyroid-specific autoantibodies, particularly anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies.
Materials and Methods:
This study combined a literature review with clinical trial analysis to evaluate the role of selenium and vitamin D in HT. A systematic approach was used to identify and assess high-quality, relevant evidence.
Results:
Selenium supplementation reduced TSH levels in patients without thyroid hormone replacement therapy (THRT) and significantly decreased TPOAb and MDA levels, with no impact on fT4, T3, or TGAb. Adverse events were rare and comparable to placebo. Vitamin D deficiency correlated with elevated TSH, anti-TPO, and anti-TG levels, with HT patients showing significantly lower vitamin D levels than healthy controls or hypothyroid patients. Both selenium and vitamin D demonstrated potential immunomodulatory benefits.
Conclusions:
Selenium and vitamin D supplementation may aid in managing HT by reducing TSH and thyroid antibody levels, emphasizing the importance of addressing micronutrient deficiencies in autoimmune thyroid disorders.
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| format | Article |
| id | doaj-art-d630a39b45a04567ab5e3114d4718d09 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-d630a39b45a04567ab5e3114d4718d092025-02-08T08:25:08ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.57938Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s ThyroiditisAgnieszka Starzyk0https://orcid.org/0009-0002-8696-4187Piotr Charzewski1https://orcid.org/0009-0007-5170-3899Medical University of WarsawKozminski University Introduction: Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress. It is characterized by chronic lymphocytic infiltration of the thyroid gland, leading to hypothyroidism and the production of thyroid-specific autoantibodies, particularly anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies. Materials and Methods: This study combined a literature review with clinical trial analysis to evaluate the role of selenium and vitamin D in HT. A systematic approach was used to identify and assess high-quality, relevant evidence. Results: Selenium supplementation reduced TSH levels in patients without thyroid hormone replacement therapy (THRT) and significantly decreased TPOAb and MDA levels, with no impact on fT4, T3, or TGAb. Adverse events were rare and comparable to placebo. Vitamin D deficiency correlated with elevated TSH, anti-TPO, and anti-TG levels, with HT patients showing significantly lower vitamin D levels than healthy controls or hypothyroid patients. Both selenium and vitamin D demonstrated potential immunomodulatory benefits. Conclusions: Selenium and vitamin D supplementation may aid in managing HT by reducing TSH and thyroid antibody levels, emphasizing the importance of addressing micronutrient deficiencies in autoimmune thyroid disorders. https://apcz.umk.pl/QS/article/view/57938hashimotoVitamin DseleniumHashimoto's thyroiditissupplementation |
| spellingShingle | Agnieszka Starzyk Piotr Charzewski Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis Quality in Sport hashimoto Vitamin D selenium Hashimoto's thyroiditis supplementation |
| title | Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis |
| title_full | Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis |
| title_fullStr | Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis |
| title_full_unstemmed | Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis |
| title_short | Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis |
| title_sort | vitamin d and selenium review of clinical trials of synergistic effects on thyroid antibody levels and disease progression in hashimoto s thyroiditis |
| topic | hashimoto Vitamin D selenium Hashimoto's thyroiditis supplementation |
| url | https://apcz.umk.pl/QS/article/view/57938 |
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