Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy
PurposeTo develop nomogram models predicting the prognosis for patients with hepatocellular carcinoma (HCC) before hepatectomy.MethodsPatients treated at the Eastern Hepatobiliary Surgery Hospital and Zhongda Hospital, Southeast University, from January 2012 to July 2014, were retrospectively enroll...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1578859/full |
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| author | Qianru Xiao Zhengqing Lei Anfeng Si Xuewu Tang Facai Yang Weihu Ma Cheng Chi Qiushi Yu Yigang He Haolan Tang Tianhang Su Fangyuan Hu Jianning Lu Youheng Yu Ziqi Liu Pinghua Yang Zhangjun Cheng |
| author_facet | Qianru Xiao Zhengqing Lei Anfeng Si Xuewu Tang Facai Yang Weihu Ma Cheng Chi Qiushi Yu Yigang He Haolan Tang Tianhang Su Fangyuan Hu Jianning Lu Youheng Yu Ziqi Liu Pinghua Yang Zhangjun Cheng |
| author_sort | Qianru Xiao |
| collection | DOAJ |
| description | PurposeTo develop nomogram models predicting the prognosis for patients with hepatocellular carcinoma (HCC) before hepatectomy.MethodsPatients treated at the Eastern Hepatobiliary Surgery Hospital and Zhongda Hospital, Southeast University, from January 2012 to July 2014, were retrospectively enrolled. Prediction models for overall survival (OS) and recurrence-free survival (RFS) were constructed.ResultsA total of 1117 patients with HCC were enrolled in this study, and were divided into a training cohort (n=838) and a validation cohort (n=279). A prediction model for OS in the training cohort (OS-nomo, C-index=0.71), including alpha-fetoprotein (AFP), estimated hepatectomy extent, and tumor burden score (TBS) as independent factors (all P<0.05), was constructed. For clinical application, we stratified all patients into three distinct risk groups: low-, medium-, and high-risk group for OS, based on total points (TPs). Patients undergoing major hepatectomy, with AFP>20 ng/mL and high level of TBS had the worst OS.ConclusionWhen selecting patients with HCC for hepatectomy, factors including sex, CPS, AFP level, estimated hepatectomy extent, and TBS should be carefully considered. OS-nomo model could serve as important tool for personalized survival prediction. |
| format | Article |
| id | doaj-art-d62e30363c7543fc83d0d54ef5f418fc |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-d62e30363c7543fc83d0d54ef5f418fc2025-08-20T03:33:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.15788591578859Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomyQianru Xiao0Zhengqing Lei1Anfeng Si2Xuewu Tang3Facai Yang4Weihu Ma5Cheng Chi6Qiushi Yu7Yigang He8Haolan Tang9Tianhang Su10Fangyuan Hu11Jianning Lu12Youheng Yu13Ziqi Liu14Pinghua Yang15Zhangjun Cheng16Department of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Hepatic Surgery IV, the Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Southeast University, Nanjing, ChinaPurposeTo develop nomogram models predicting the prognosis for patients with hepatocellular carcinoma (HCC) before hepatectomy.MethodsPatients treated at the Eastern Hepatobiliary Surgery Hospital and Zhongda Hospital, Southeast University, from January 2012 to July 2014, were retrospectively enrolled. Prediction models for overall survival (OS) and recurrence-free survival (RFS) were constructed.ResultsA total of 1117 patients with HCC were enrolled in this study, and were divided into a training cohort (n=838) and a validation cohort (n=279). A prediction model for OS in the training cohort (OS-nomo, C-index=0.71), including alpha-fetoprotein (AFP), estimated hepatectomy extent, and tumor burden score (TBS) as independent factors (all P<0.05), was constructed. For clinical application, we stratified all patients into three distinct risk groups: low-, medium-, and high-risk group for OS, based on total points (TPs). Patients undergoing major hepatectomy, with AFP>20 ng/mL and high level of TBS had the worst OS.ConclusionWhen selecting patients with HCC for hepatectomy, factors including sex, CPS, AFP level, estimated hepatectomy extent, and TBS should be carefully considered. OS-nomo model could serve as important tool for personalized survival prediction.https://www.frontiersin.org/articles/10.3389/fonc.2025.1578859/fullhepatocellular carcinoma (HCC)tumor burden score (TBS)hepatectomyalphafetoprotein (AFP)estimated hepatectomy extent |
| spellingShingle | Qianru Xiao Zhengqing Lei Anfeng Si Xuewu Tang Facai Yang Weihu Ma Cheng Chi Qiushi Yu Yigang He Haolan Tang Tianhang Su Fangyuan Hu Jianning Lu Youheng Yu Ziqi Liu Pinghua Yang Zhangjun Cheng Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy Frontiers in Oncology hepatocellular carcinoma (HCC) tumor burden score (TBS) hepatectomy alphafetoprotein (AFP) estimated hepatectomy extent |
| title | Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy |
| title_full | Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy |
| title_fullStr | Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy |
| title_full_unstemmed | Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy |
| title_short | Nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy |
| title_sort | nomogram based on tumor burden score for prediction of prognosis of patients with hepatocellular carcinoma before hepatectomy |
| topic | hepatocellular carcinoma (HCC) tumor burden score (TBS) hepatectomy alphafetoprotein (AFP) estimated hepatectomy extent |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1578859/full |
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