The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis
The transient receptor potential vanilloid 1 (TRPV1) may play a role in the pathogenesis of ulcerative colitis (UC). The aim of the study was to determine the gene and protein expression of TRPV1 in UC patients and noninflamed controls. Gene expression was performed by RT-PCR, and protein expression...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/6570371 |
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| author | Joel Jesús Toledo-Mauriño Janette Furuzawa-Carballeda Marco A. Villeda-Ramírez Gabriela Fonseca-Camarillo Daniela Meza-Guillen Rafael Barreto-Zúñiga Jesús K. Yamamoto-Furusho |
| author_facet | Joel Jesús Toledo-Mauriño Janette Furuzawa-Carballeda Marco A. Villeda-Ramírez Gabriela Fonseca-Camarillo Daniela Meza-Guillen Rafael Barreto-Zúñiga Jesús K. Yamamoto-Furusho |
| author_sort | Joel Jesús Toledo-Mauriño |
| collection | DOAJ |
| description | The transient receptor potential vanilloid 1 (TRPV1) may play a role in the pathogenesis of ulcerative colitis (UC). The aim of the study was to determine the gene and protein expression of TRPV1 in UC patients and noninflamed controls. Gene expression was performed by RT-PCR, and protein expression was performed by immunohistochemistry. The gene expression of TRPV1 was significantly increased in the remission UC group compared to active UC patients (P=0.002), and an upregulation of the TRPV1 gene was associated with clinical outcomes such as age at diagnosis (<40 years) (P=0.02) and clinical disease course characterized by relapsing and continuous activity (P=0.07). TRPV1 immunoreactive cells were conspicuously higher in all intestinal layers from active UC patients compared with noninflamed control tissue. These findings suggest that TRPV1 might be involved in UC pathogenesis. |
| format | Article |
| id | doaj-art-d62cc18ee7734007ab636e1e6d56b853 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d62cc18ee7734007ab636e1e6d56b8532025-08-20T03:23:39ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/65703716570371The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative ColitisJoel Jesús Toledo-Mauriño0Janette Furuzawa-Carballeda1Marco A. Villeda-Ramírez2Gabriela Fonseca-Camarillo3Daniela Meza-Guillen4Rafael Barreto-Zúñiga5Jesús K. Yamamoto-Furusho6Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Endoscopy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Endoscopy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoThe transient receptor potential vanilloid 1 (TRPV1) may play a role in the pathogenesis of ulcerative colitis (UC). The aim of the study was to determine the gene and protein expression of TRPV1 in UC patients and noninflamed controls. Gene expression was performed by RT-PCR, and protein expression was performed by immunohistochemistry. The gene expression of TRPV1 was significantly increased in the remission UC group compared to active UC patients (P=0.002), and an upregulation of the TRPV1 gene was associated with clinical outcomes such as age at diagnosis (<40 years) (P=0.02) and clinical disease course characterized by relapsing and continuous activity (P=0.07). TRPV1 immunoreactive cells were conspicuously higher in all intestinal layers from active UC patients compared with noninflamed control tissue. These findings suggest that TRPV1 might be involved in UC pathogenesis.http://dx.doi.org/10.1155/2018/6570371 |
| spellingShingle | Joel Jesús Toledo-Mauriño Janette Furuzawa-Carballeda Marco A. Villeda-Ramírez Gabriela Fonseca-Camarillo Daniela Meza-Guillen Rafael Barreto-Zúñiga Jesús K. Yamamoto-Furusho The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis Mediators of Inflammation |
| title | The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis |
| title_full | The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis |
| title_fullStr | The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis |
| title_full_unstemmed | The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis |
| title_short | The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis |
| title_sort | transient receptor potential vanilloid 1 is associated with active inflammation in ulcerative colitis |
| url | http://dx.doi.org/10.1155/2018/6570371 |
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