Brain milieu induces early microglial maturation through the BAX-Notch axis

Brain milieu induces early microglial maturation through the BAX-Notch axis

Abstract Microglia are derived from primitive myeloid cells and gain their early identity in the embryonic brains. However, the mechanism by which the brain milieu confers microglial maturation signature remains elusive. Here, we demonstrate that the bax cq55 zebrafish and Bax tm1Sjk mouse embryos e...

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Bibliographic Details
Main Authors: Fangying Zhao, Jiangyong He, Jun Tang, Nianfei Cui, Yanyan Shi, Zhifan Li, Shengnan Liu, Yazhou Wang, Ming Ma, Congjian Zhao, Lingfei Luo, Li Li
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33836-2
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