Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review
PURPOSE Physical activity induces metabolic changes in the body. However, the biological mechanisms underlying these metabolic changes remain unclear. Metabolomics has advanced the field of exercise science, although most studies use invasive procedures for sample collection and have low rates of pa...
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| Format: | Article |
| Language: | Korean |
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The Korean Society of Exercise Physiology
2025-05-01
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| Series: | 운동과학 |
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| Online Access: | http://ksep-es.org/upload/pdf/ksep-2025-00269.pdf |
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| author | Zi-Xiao Yu Ji-Suk Chang Ah-Ram Kim Ho-Seong Lee |
| author_facet | Zi-Xiao Yu Ji-Suk Chang Ah-Ram Kim Ho-Seong Lee |
| author_sort | Zi-Xiao Yu |
| collection | DOAJ |
| description | PURPOSE Physical activity induces metabolic changes in the body. However, the biological mechanisms underlying these metabolic changes remain unclear. Metabolomics has advanced the field of exercise science, although most studies use invasive procedures for sample collection and have low rates of participant compliance. METHODS A systematic literature search was conducted between March 30 and April 5, 2024, to identify articles published between January 1, 2004 and January 1, 2024, across four academic databases: Web of Science, Google Scholar, PubMed, and Scopus. RESULTS This review analyzed 34 original research articles on urinary metabolomics in exercise science. NMR and mass spectrometry platforms were used in similar proportions of the studies, accounting for 41.2% (14/34) and 35.3% (12/34) of the studies, respectively. Untargeted approaches dominated research, accounting for 85.3% of studies (n=29), whereas targeted methodologies were exclusively used in only 14.7% (n=5). CONCLUSIONS Urinary metabolomics is rapidly emerging as a valuable tool in the field of exercise science. Untargeted approaches have mainly been used owing to their capability to capture exercise-induced metabolic responses comprehensively. Advancements in analytical technologies are expected to accelerate multi-omics integration, enabling precise characterization of physiological adaptations and supporting personalized strategies for health and performance enhancement. |
| format | Article |
| id | doaj-art-d61d8a91f05b41079f8b58838550e06e |
| institution | Kabale University |
| issn | 1226-1726 2384-0544 |
| language | Korean |
| publishDate | 2025-05-01 |
| publisher | The Korean Society of Exercise Physiology |
| record_format | Article |
| series | 운동과학 |
| spelling | doaj-art-d61d8a91f05b41079f8b58838550e06e2025-08-20T03:44:58ZkorThe Korean Society of Exercise Physiology운동과학1226-17262384-05442025-05-013429510710.15857/ksep.2025.002691134Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic ReviewZi-Xiao Yu0Ji-Suk Chang1Ah-Ram Kim2Ho-Seong Lee3Department of Exercise and Medical Science, Graduate School, Dankook University, Cheonan, KoreaDepartment of Sport Management, College of Sports Science, Dankook University, Cheonan, KoreaDepartment of Sports Medicine, Graduate School of Sport Science, Dankook University, Cheonan, KoreaDepartment of Exercise and Medical Science, Graduate School, Dankook University, Cheonan, KoreaPURPOSE Physical activity induces metabolic changes in the body. However, the biological mechanisms underlying these metabolic changes remain unclear. Metabolomics has advanced the field of exercise science, although most studies use invasive procedures for sample collection and have low rates of participant compliance. METHODS A systematic literature search was conducted between March 30 and April 5, 2024, to identify articles published between January 1, 2004 and January 1, 2024, across four academic databases: Web of Science, Google Scholar, PubMed, and Scopus. RESULTS This review analyzed 34 original research articles on urinary metabolomics in exercise science. NMR and mass spectrometry platforms were used in similar proportions of the studies, accounting for 41.2% (14/34) and 35.3% (12/34) of the studies, respectively. Untargeted approaches dominated research, accounting for 85.3% of studies (n=29), whereas targeted methodologies were exclusively used in only 14.7% (n=5). CONCLUSIONS Urinary metabolomics is rapidly emerging as a valuable tool in the field of exercise science. Untargeted approaches have mainly been used owing to their capability to capture exercise-induced metabolic responses comprehensively. Advancements in analytical technologies are expected to accelerate multi-omics integration, enabling precise characterization of physiological adaptations and supporting personalized strategies for health and performance enhancement.http://ksep-es.org/upload/pdf/ksep-2025-00269.pdfurineexercise physiologymetabolomicstargeteduntargeted |
| spellingShingle | Zi-Xiao Yu Ji-Suk Chang Ah-Ram Kim Ho-Seong Lee Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review 운동과학 urine exercise physiology metabolomics targeted untargeted |
| title | Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review |
| title_full | Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review |
| title_fullStr | Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review |
| title_full_unstemmed | Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review |
| title_short | Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review |
| title_sort | targeted and untargeted urinary metabolomics in exercise science a systematic review |
| topic | urine exercise physiology metabolomics targeted untargeted |
| url | http://ksep-es.org/upload/pdf/ksep-2025-00269.pdf |
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