Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

BackgroundBy employing a high-dimensionality approach, this study aims to identify mechanistically relevant cellular immune signatures that predict poor outcomes.MethodsThis prospective study recruited 39 children with sepsis admitted to the intensive care unit and 19 healthy age-matched children. P...

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Main Authors: Dandan Pi, Judith Ju Ming Wong, Katherine Nay Yaung, Nicholas Kim Huat Khoo, Su Li Poh, Martin Wasser, Pavanish Kumar, Thaschawee Arkachaisri, Feng Xu, Herng Lee Tan, Yee Hui Mok, Joo Guan Yeo, Salvatore Albani
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
sepsis
severe sepsis
septic shock
pediatric intensive care units
monocytes
Th17 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569096/full
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