Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
Schizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/832757 |
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| author | Gerburg Keilhoff Paolo Fusar-Poli Axel Becker |
| author_facet | Gerburg Keilhoff Paolo Fusar-Poli Axel Becker |
| author_sort | Gerburg Keilhoff |
| collection | DOAJ |
| description | Schizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in neurodevelopment might result in alterations of neuroanatomy and neurochemistry, leading to the typical symptoms observed in schizophrenia. The present paper will critically address the neurodevelopmental models underlying schizophrenia by discussing the effects of typical and atypical antipsychotics in animal models. We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset. |
| format | Article |
| id | doaj-art-d61bacaa5fa448dd823663eb5e540f12 |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d61bacaa5fa448dd823663eb5e540f122025-08-20T03:23:42ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/832757832757Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical UpdateGerburg Keilhoff0Paolo Fusar-Poli1Axel Becker2Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Straße 44, 39120 Magdeburg, GermanyInstitute of Psychiatry, King's College London, 5th Floor, Main Building, P.O. Box 63, De Crespigny Park, London SE5 8AF, UKInstitute of Pharmacology and Toxicology, University of Magdeburg, Leipziger Straße 44, 39120 Magdeburg, GermanySchizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in neurodevelopment might result in alterations of neuroanatomy and neurochemistry, leading to the typical symptoms observed in schizophrenia. The present paper will critically address the neurodevelopmental models underlying schizophrenia by discussing the effects of typical and atypical antipsychotics in animal models. We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset.http://dx.doi.org/10.1155/2012/832757 |
| spellingShingle | Gerburg Keilhoff Paolo Fusar-Poli Axel Becker Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update Neural Plasticity |
| title | Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update |
| title_full | Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update |
| title_fullStr | Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update |
| title_full_unstemmed | Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update |
| title_short | Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update |
| title_sort | effects of antipsychotics on dentate gyrus stem cell proliferation and survival in animal models a critical update |
| url | http://dx.doi.org/10.1155/2012/832757 |
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