Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches

Food flavor, a blend of taste and smell, is key to consumer acceptance and food quality. Traditional sensory and instrumental methods often fail to replicate human sensory responses. This review discusses the role of cell-based biosensors in flavor evaluation, showcasing their sensitivity, specifici...

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Main Authors: Mahmoud Said Rashed, Esraa A. Abdelkarim, Tamer Elsamahy, Mabrouk Sobhy, Hany S. El-Mesery, Ali Salem
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Food Chemistry: X
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Online Access:http://www.sciencedirect.com/science/article/pii/S259015752500183X
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author Mahmoud Said Rashed
Esraa A. Abdelkarim
Tamer Elsamahy
Mabrouk Sobhy
Hany S. El-Mesery
Ali Salem
author_facet Mahmoud Said Rashed
Esraa A. Abdelkarim
Tamer Elsamahy
Mabrouk Sobhy
Hany S. El-Mesery
Ali Salem
author_sort Mahmoud Said Rashed
collection DOAJ
description Food flavor, a blend of taste and smell, is key to consumer acceptance and food quality. Traditional sensory and instrumental methods often fail to replicate human sensory responses. This review discusses the role of cell-based biosensors in flavor evaluation, showcasing their sensitivity, specificity, and rapid response. Using living cells like taste and olfactory cells, these biosensors surpass traditional approaches. Advancements include microelectrode array systems with taste receptor cells for real-time detection of bitter, sweet, and umami substances and improved cell immobilization technologies for detecting complex odorant profiles. Challenges such as signal stability, selective detection, cell cultivation, and scalability persist. However, integrating artificial intelligence and portable technologies could broaden their applications. With the potential to revolutionize sensory analysis, cell-based biosensors offer a sustainable, precise, and scalable approach to food flavor evaluation, bridging sensory perception with advanced analytical methods and driving innovation in food science.
format Article
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institution DOAJ
issn 2590-1575
language English
publishDate 2025-02-01
publisher Elsevier
record_format Article
series Food Chemistry: X
spelling doaj-art-d619fd2597484ea8af6daaef8148229b2025-08-20T03:15:28ZengElsevierFood Chemistry: X2590-15752025-02-012610233610.1016/j.fochx.2025.102336Advances in cell-based biosensors: Transforming food flavor evaluation with novel approachesMahmoud Said Rashed0Esraa A. Abdelkarim1Tamer Elsamahy2Mabrouk Sobhy3Hany S. El-Mesery4Ali Salem5Food Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria 21545, EgyptFood Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, EgyptIndependent researcher, Zhenjiang 212013, ChinaFood Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt; School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Energy and Power Engineering, Jiangsu University, Zhenjiang 212013, China; Agricultural Engineering Research Institute, Agricultural Research Center, Dokki, 12611 Giza, Egypt; Corresponding author at: School of Energy and Power Engineering, Jiangsu University, Zhenjiang 212013, China.Civil Engineering Department, Faculty of Engineering, Minia University, Minia 61111, Egypt; Structural Diagnostics and Analysis Research Group, Faculty of Engineering and Information Technology, University of Pecs, Hungary; Corresponding author at: Structural Diagnostics and Analysis Research Group, Faculty of Engineering and Information Technology, University of P ́ecs, Hungary.Food flavor, a blend of taste and smell, is key to consumer acceptance and food quality. Traditional sensory and instrumental methods often fail to replicate human sensory responses. This review discusses the role of cell-based biosensors in flavor evaluation, showcasing their sensitivity, specificity, and rapid response. Using living cells like taste and olfactory cells, these biosensors surpass traditional approaches. Advancements include microelectrode array systems with taste receptor cells for real-time detection of bitter, sweet, and umami substances and improved cell immobilization technologies for detecting complex odorant profiles. Challenges such as signal stability, selective detection, cell cultivation, and scalability persist. However, integrating artificial intelligence and portable technologies could broaden their applications. With the potential to revolutionize sensory analysis, cell-based biosensors offer a sustainable, precise, and scalable approach to food flavor evaluation, bridging sensory perception with advanced analytical methods and driving innovation in food science.http://www.sciencedirect.com/science/article/pii/S259015752500183XFlavorConsumer acceptanceCell sensorsTransducersCell immobilization
spellingShingle Mahmoud Said Rashed
Esraa A. Abdelkarim
Tamer Elsamahy
Mabrouk Sobhy
Hany S. El-Mesery
Ali Salem
Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches
Food Chemistry: X
Flavor
Consumer acceptance
Cell sensors
Transducers
Cell immobilization
title Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches
title_full Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches
title_fullStr Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches
title_full_unstemmed Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches
title_short Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches
title_sort advances in cell based biosensors transforming food flavor evaluation with novel approaches
topic Flavor
Consumer acceptance
Cell sensors
Transducers
Cell immobilization
url http://www.sciencedirect.com/science/article/pii/S259015752500183X
work_keys_str_mv AT mahmoudsaidrashed advancesincellbasedbiosensorstransformingfoodflavorevaluationwithnovelapproaches
AT esraaaabdelkarim advancesincellbasedbiosensorstransformingfoodflavorevaluationwithnovelapproaches
AT tamerelsamahy advancesincellbasedbiosensorstransformingfoodflavorevaluationwithnovelapproaches
AT mabrouksobhy advancesincellbasedbiosensorstransformingfoodflavorevaluationwithnovelapproaches
AT hanyselmesery advancesincellbasedbiosensorstransformingfoodflavorevaluationwithnovelapproaches
AT alisalem advancesincellbasedbiosensorstransformingfoodflavorevaluationwithnovelapproaches