Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplot...
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| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/373876 |
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| author | Yani Lu Amr M. Abdou James R. Cerhan Lindsay M. Morton Richard K. Severson Scott Davis Wendy Cozen Nathaniel Rothman Leslie Bernstein Stephen Chanock Patricia Hartge Sophia S. Wang |
| author_facet | Yani Lu Amr M. Abdou James R. Cerhan Lindsay M. Morton Richard K. Severson Scott Davis Wendy Cozen Nathaniel Rothman Leslie Bernstein Stephen Chanock Patricia Hartge Sophia S. Wang |
| author_sort | Yani Lu |
| collection | DOAJ |
| description | Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLAA*01-B*08-DRB1*03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw*07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR] = 1.76, 95% confidence interval [CI] = 1.01–3.05); HLA-A*01:01 was associated with poorer OS (HR = 2.23, 95% CI = 1.24–4.01), and HLA-DRB1*13 (HR = 0.12, 95% CI = 0.02–0.90) and HLA-B Bw4 (HR = 0.36, 95% CI = 0.20–0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation. |
| format | Article |
| id | doaj-art-d6186c6f963a488ca8472015164da688 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d6186c6f963a488ca8472015164da6882025-02-03T01:22:48ZengWileyThe Scientific World Journal1537-744X2011-01-01112062207010.1100/2011/373876373876Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular LymphomaYani Lu0Amr M. Abdou1James R. Cerhan2Lindsay M. Morton3Richard K. Severson4Scott Davis5Wendy Cozen6Nathaniel Rothman7Leslie Bernstein8Stephen Chanock9Patricia Hartge10Sophia S. Wang11Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USADepartment of Microbiology and Immunology, National Research Center, Cairo, EgyptMayo Clinic, College of Medicine, Rochester, MN 55905, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USADepartment of Family Medicine and Public Health Sciences, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48202, USAFred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109-4433, USANorris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USADivision of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USADivision of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USAGenetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLAA*01-B*08-DRB1*03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw*07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR] = 1.76, 95% confidence interval [CI] = 1.01–3.05); HLA-A*01:01 was associated with poorer OS (HR = 2.23, 95% CI = 1.24–4.01), and HLA-DRB1*13 (HR = 0.12, 95% CI = 0.02–0.90) and HLA-B Bw4 (HR = 0.36, 95% CI = 0.20–0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.http://dx.doi.org/10.1100/2011/373876 |
| spellingShingle | Yani Lu Amr M. Abdou James R. Cerhan Lindsay M. Morton Richard K. Severson Scott Davis Wendy Cozen Nathaniel Rothman Leslie Bernstein Stephen Chanock Patricia Hartge Sophia S. Wang Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma The Scientific World Journal |
| title | Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma |
| title_full | Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma |
| title_fullStr | Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma |
| title_full_unstemmed | Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma |
| title_short | Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma |
| title_sort | human leukocyte antigen class i and ii alleles and overall survival in diffuse large b cell lymphoma and follicular lymphoma |
| url | http://dx.doi.org/10.1100/2011/373876 |
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